ArticleHuman brain mapping2018
Cortical depth profiles of luminance contrast responses in human V1 and V2 using 7 T fMRI.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Model-based estimation of the population contrast response function in human visual cortex.Journal of vision · 2026Article
- Re-emergence of orientation coding in primate IT cortex and deep networks reveals functional hubs for visual processing.bioRxiv : the preprint server for biology · 2026Article
- Modulation of Visual Contrast Perception Associated With Dorsal Attention Network Connectivity Assessed by Magnetoencephalography.Human brain mapping · 2026Article
- Bridging the gap with invasive imaging: promises and challenges of a new generation of ultrahigh resolution fMRI.bioRxiv : the preprint server for biology · 2026Article
- Cortical-layer EEG-fMRI at 7T: experimental setup and analysis pipeline to elucidate generating mechanisms of alpha oscillations.bioRxiv : the preprint server for biology · 2025Article
- Article
- In the brain of the beholder: bi-stable motion reveals mesoscopic-scale feedback modulation in V1.Brain structure & function · 2025Article
- The laminar pattern of proprioceptive activation in human primary motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Detectability and cortical depth dependence of stimulus-driven high-frequency BOLD oscillations in the human primary somatosensory and motor cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Modeling neural contrast sensitivity functions in human visual cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Mapping the dynamics of visual feature coding: Insights into perception and integration.PLoS computational biology · 2024Article
- Cortical depth profiles of auditory and visual 7 T functional MRI responses in human superior temporal areas.Human brain mapping · 2023Article
- Cortical depth-dependent human fMRI of resting-state networks using EPIK.Frontiers in neuroscience · 2023Article
- Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7T: Challenges and capabilities.PloS one · 2023Article
- Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field.Nature communications · 2022Article
- Neuroimaging at 7 Tesla: a pictorial narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Saturating Nonlinearities of Contrast Response in Human Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Laminar functional magnetic resonance imaging in vision research.Frontiers in neuroscience · 2022Review
- Pre-processing of Sub-millimeter GE-BOLD fMRI Data for Laminar Applications.Frontiers in neuroimaging · 2022Article
- Investigating mechanisms of fast BOLD responses: The effects of stimulus intensity and of spatial heterogeneity of hemodynamics.NeuroImage · 2021Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Neural activity in early visual cortex is modulated by luminance contrast. Cortical depth (i.e., laminar) contrast responses have been studied in monkey early visual cortex, but not in humans. In addition to the high spatial resolution needed and the ensuing low signal-to-noise ratio, laminar studies in humans using fMRI are hampered by the strong venous vascular weighting of the fMRI signal. In this study, we measured luminance contrast responses in human V1 and V2 with high-resolution fMRI at 7 T. To account for the effect of intracortical ascending veins, we applied a novel spatial deconvolution model to the fMRI depth profiles. Before spatial deconvolution, the contrast response in V1 showed a slight local maximum at mid cortical depth, whereas V2 exhibited a monotonic signal increase toward the cortical surface. After applying the deconvolution, both V1 and V2 showed a pronounced local maximum at mid cortical depth, with an additional peak in deep grey matter, especially in V1. Moreover, we found a difference in contrast sensitivity between V1 and V2, but no evidence for variations in contrast sensitivity as a function of cortical depth. These findings are in agreement with results obtained in nonhuman primates, but further research will be needed to validate the spatial deconvolution approach.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.