ArticleNeurogastroenterology and motility2018
High temporal resolution gastric emptying breath tests in mice.
Article in Neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Ingestible probes for breath-based monitoring of drug-metabolizing activity from the microbiome.Science advances · 2026Article
- Silk-based biomimetic nanocomposite for precision eradication of Helicobacter pylori and gut microbiome preservation.Journal of nanobiotechnology · 2026Article
- Polyphenol-modified probiotics for the enhanced survivability, persistence and colonization of probiotic cells in the gut.Current research in food science · 2026Article
- Hypoxia-Inducible Factor 1α Stabilization Restores Epigenetic Control of Nitric Oxide Synthase 1 Expression and Reverses Gastroparesis in Female Diabetic Mice.Gastroenterology · 2023Article
- Adeno-associated virus-9 reverses delayed gastric emptying of solids in diabetic mice.Neurogastroenterology and motility · 2023Article
- Brainstem astrocytes control homeostatic regulation of caloric intake.The Journal of physiology · 2023Article
- Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.Gastroenterology · 2022Article
- Hypothalamic-vagal oxytocinergic neurocircuitry modulates gastric emptying and motility following stress.The Journal of physiology · 2020Article
- Improved Imaging of Zebrafish Motility.Neurogastroenterology and motility · 2018Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
backgroundGastric emptying is a complex physiological process regulating the division of a meal into smaller partitions for the small intestine. Disrupted gastric emptying contributes to digestive disease, yet current measures may not reflect different mechanisms by which the process can be altered.
methodsWe have developed high temporal resolution solid and liquid gastric emptying breath tests in mice using [ KEY
resultsThese assays detect acceleration and delay using pharmacological (7.5 mg/kg atropine) or physiological (nutrients, cold exposure stress, diabetes) manipulations and remain stable over time. High temporal resolution resolved complex excretion curves with 2 components, which was more prevalent in mice with delayed gastric emptying following streptozotocin-induced diabetes. There were differences in the gastric emptying of Balb/c vs C57Bl6 mice, with slower gastric emptying and a greater occurrence of two-phase gastric emptying curves in the latter strain. Gastric emptying of C57Bl6 could be accelerated by halving the meal size, but with no effect on the occurrence of two-phase gastric emptying curves. A greater proportion of two-phase gastric emptying was induced in Balb/c mice with the administration of PYY (8-80 nmol) 60 min following meal ingestion. CONCLUSIONS AND INFERENCES: Collectively, these results demonstrate the utility of high temporal resolution gastric emptying assays. Two-phase gastric emptying is more prevalent than previously reported, likely involves intestinal feedback, but contributes little to the overall rate of gastric emptying.
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