Evidence map›Paper›PMID 29575396›Full record

ArticlePediatric transplantation2018

Changes in left ventricular strain parameters following pediatric heart transplantation.

Justin Godown, Debra A Dodd, Michael Stanley, Corey Havens, Meng Xu, James C Slaughter, David W Bearl, Jonathan H Soslow

Abstract read
In one paragraph

Article in Pediatric transplantation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Cardiac magnetic resonance assessment of acute rejection and cardiac allograft vasculopathy in pediatric heart transplant.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
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  8. Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Justin GodownDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.ORCID 0000-0002-7068-0625
Debra A DoddDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.
Michael StanleyDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.
Corey HavensDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.
Meng XuDepartment of Biostatistics, Vanderbilt University, Nashville, TN, USA.
James C SlaughterDepartment of Biostatistics, Vanderbilt University, Nashville, TN, USA.
David W BearlDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.
Jonathan H SoslowDepartment of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA.ORCID 0000-0001-9194-5330

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
Quantitative Assessment of Cardiac Disease in Duchenne Muscular DystrophyK23HL123938 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SOSLOW, JONATHAN HARVEY · 2014 to 2018
$829k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K23 HL123938
6 · The paper itself

Abstract

STE is increasingly utilized to assess strain in a variety of pathologies. Strain measurements have demonstrated utility following HTx and may aid in the detection of rejection and CAV. Strain parameters have not been well defined in the pediatric HTx population. This study aimed to describe strain in pediatric HTx recipients compared to controls and assess changes over time. All pediatric HTx recipients with available echocardiograms (2004-2015) without rejection or CAV were identified. Longitudinal and circumferential strain was measured at <1 month, 1 year, 3 years, and 5 years post-transplant and compared to controls. A total of 218 echocardiograms were analyzed in 79 HTx recipients. At <1 month post-transplant, there was a significant decrement in longitudinal strain (GLS -14.6 vs -19.2, P < .001) with concurrent augmentation of circumferential strain (GCS -27.3 vs -24.3, P = .005). By 1 year post-HTx, all strain parameters normalized and were not significantly different from the control population. In the absence of graft complications, strain parameters did not change up to 5 years post-transplant. Abnormal longitudinal strain parameters are present in the early post-HTx period with a compensatory increase in circumferential strain. These changes normalize by 1 year post-transplant and do not change over time in the absence of graft complications.

Indexed as

Heart TransplantationAdolescentCase-Control StudiesChildChild, PreschoolEchocardiographyFemaleFollow-Up StudiesHeart VentriclesHumansInfantInfant, NewbornMalePostoperative ComplicationsReference ValuesRetrospective Studiesechocardiographypediatric heart transplantstrain

Identifiers

PMID29575396
PMCPMC6047919

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.