ArticleMagnetic resonance in medicine2018
Simultaneous measurement of glutamate, glutamine, GABA, and glutathione by spectral editing without subtraction.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Meta-analysis and open-source database for in vivo brain Magnetic Resonance spectroscopy in health and disease.Analytical biochemistry · 2023Pooled it
- Comparative evaluation of a deep learning method QNet and LCModel for MRS quantification on the cloud computing platform CloudBrain-MRS.BMC medical imaging · 2026Article
- Simultaneous in vivo detection of spectrally resolved glutamate, glutamine, and glutathione at 3 T with NAA-aspartyl editing and echo-time optimization.Magnetic resonance in medicine · 2026Article
- Thalamic GABA+ levels are negatively associated with neuropsychiatric symptoms in patients with insomnia.Frontiers in human neuroscience · 2026Article
- In vivo GABA detection by single-pulse editing with one shot.Magnetic resonance in medicine · 2025Article
- Universal dynamic fitting of magnetic resonance spectroscopy.Magnetic resonance in medicine · 2024Article
- Meta-analysis and Open-source Database for In Vivo Brain Magnetic Resonance Spectroscopy in Health and Disease.bioRxiv : the preprint server for biology · 2023Article
- Detection ofScientific reports · 2022Article
- Glutamine Imaging: A New Avenue for Glioma Management.AJNR. American journal of neuroradiology · 2022Review
- Determination of Brain Metabolite TJournal of magnetic resonance imaging : JMRI · 2020Article
- Signal enhancement of glutamine and glutathione by single-step spectral editing.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2020Article
- Simultaneous editing of GABA and GSH with Hadamard-encoded MR spectroscopic imaging.Magnetic resonance in medicine · 2019Article
- Effects of carrier frequency mismatch on frequency-selective spectral editing.Magma (New York, N.Y.) · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo simultaneously measure glutamate, glutamine, γ-aminobutyric acid (GABA), and glutathione using spectral editing without subtraction at 7T.
methodsA novel spectral editing approach was proposed to simultaneously measure glutamate, glutamine, GABA, and glutathione using a TE of 56 ms at 7T. By numerical optimization of sequence timing in the presence of an editing pulse, the 4 metabolites all form relatively intense pseudo singlets with maximized peak amplitudes and minimized peak linewidths in 1 of the 3 interleaved spectra. For measuring glutamate, glutamine, and glutathione, the editing pulse targets the H
resultsConcentration levels (/[total creatine]) of glutamate, glutamine, GABA, and glutathione from an 8 mL voxel in the pregenual anterior cingulate cortex of 5 healthy volunteers were found to be 1.26 ± 0.13, 0.33 ± 0.06, 0.13 ± 0.03, and 0.27 ± 0.03, respectively, with within-subject coefficient of variation at 3.2%, 8.2%, 7.1%, and 10.2%, respectively. The total scan time was less than 4.5 min.
conclusionsThe proposed new technique does not require data subtraction. The 3 major metabolites of the glutamatergic and GABAergic systems and the oxidative stress marker glutathione were all measured in 1 short scan with high precision.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.