ArticleMagnetic resonance in medicine2018
Assessment of MR-based R2* and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- TFR2 p.A75V mutation aggravates liver iron overload in alcoholic liver disease via ERK pathway.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Liver iron susceptometry is different in patients with transfusion dependent thalassemia and sickle cell disease compared with hemochromatosis.Biochemistry and biophysics reports · 2025Article
- Article
- Abdominal magnetic resonance imaging examination of Tibetan patients with abnormal iron metabolism and a preliminary study of correlations with blood cell analysis.The Journal of international medical research · 2020Observational
- Sensitivity of quantitative relaxometry and susceptibility mapping to microscopic iron distribution.Magnetic resonance in medicine · 2020Article
- Quantitative ferumoxytol-enhanced MRI in pregnancy: A feasibility study in the nonhuman primate.Magnetic resonance imaging · 2020Article
- Fat spectral modeling on triglyceride composition quantification using chemical shift encoded magnetic resonance imaging.Magnetic resonance imaging · 2018Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo assess the feasibility of quantifying liver iron concentration (LIC) using R2* and quantitative susceptibility mapping (QSM) at a high field strength of 7 Tesla (T).
methodsFive different concentrations of Fe-dextran were injected into 12 mice to produce various degrees of liver iron overload. After mice were sacrificed, blood and liver samples were harvested. Ferritin enzyme-linked immunosorbent assay (ELISA) and inductively coupled plasma mass spectrometry were performed to quantify serum ferritin concentration and LIC. Multiecho gradient echo MRI was conducted to estimate R2* and the magnetic susceptibility of each liver sample through complex nonlinear least squares fitting and a morphology enabled dipole inversion method, respectively.
resultsAverage estimates of serum ferritin concentration, LIC, R2*, and susceptibility all show good linear correlations with injected Fe-dextran concentration; however, the standard deviations in the estimates of R2* and susceptibility increase with injected Fe-dextran concentration. Both R2* and susceptibility measurements also show good linear correlations with LIC (R
conclusionThe feasibility of quantifying LIC using MR-based R2* and QSM at a high field strength of 7T is demonstrated. Susceptibility quantification, which is an intrinsic property of tissues and benefits from being field-strength independent, is more robust than R2* quantification in this ex vivo study. A susceptibility-to-LIC conversion factor is presented that agrees relatively well with previously published QSM derived results obtained at 1.5T and 3T.
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