Evidence map›Paper›PMID 29574976›Full record

ArticleYeast (Chichester, England)2018

Database for High Throughput Screening Hits (dHITS): a simple tool to retrieve gene specific phenotypes from systematic screens done in yeast.

Silvia G Chuartzman, Maya Schuldiner

Open access · hybridAbstract read
In one paragraph

Article in Yeast (Chichester, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Spatial proteomics: a powerful discovery tool for cell biology.Nature reviews. Molecular cell biology · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Silvia G ChuartzmanDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.
Maya SchuldinerDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, 7610001, Israel.ORCID 0000-0001-9947-115X
Weizmann Institute of Science · IL

Funding

European Research Council 646604
6 · The paper itself

Abstract

In the last decade several collections of Saccharomyces cerevisiae yeast strains have been created. In these collections every gene is modified in a similar manner such as by a deletion or the addition of a protein tag. Such libraries have enabled a diversity of systematic screens, giving rise to large amounts of information regarding gene functions. However, often papers describing such screens focus on a single gene or a small set of genes and all other loci affecting the phenotype of choice ('hits') are only mentioned in tables that are provided as supplementary material and are often hard to retrieve or search. To help unify and make such data accessible, we have created a Database of High Throughput Screening Hits (dHITS). The dHITS database enables information to be obtained about screens in which genes of interest were found as well as the other genes that came up in that screen - all in a readily accessible and downloadable format. The ability to query large lists of genes at the same time provides a platform to easily analyse hits obtained from transcriptional analyses or other screens. We hope that this platform will serve as a tool to facilitate investigation of protein functions to the yeast community.

Indexed as

Databases, GeneticGene LibraryDatabase Management SystemsData MiningGene DeletionGenome, FungalGreen Fluorescent ProteinsHigh-Throughput Screening AssaysPhenotypeSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsGreen Fluorescent ProteinsSaccharomyces cerevisiae Proteinsdatabasedeletion librarydHITSGFP libraryphenotypeSaccharomyces cerevisiaesystematic screensyeast libraries

Identifiers

PMID29574976
PMCPMC6055851
OpenAlexW2791389692

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.