Evidence map›Paper›PMID 29574954›Full record

ArticleAmerican journal of industrial medicine2018

Clinical and laboratory factors contributing to uninterpretable beryllium lymphocyte proliferation tests (BeLPT).

Derek E Smith, Ashley P Golden, Arthur W Stange, Elizabeth Barker, Margaret Mroz, Anna E Barón, Debashis Ghosh, Lisa Maier, Donna Cragle, Lee S Newman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of industrial medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Derek E SmithCancer Center Biostatistics Core, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.ORCID 0000-0001-8117-2477
Ashley P GoldenOak Ridge Associated Universities, Oak Ridge, Tennessee.ORCID 0000-0002-9430-7702
Arthur W StangeOak Ridge Associated Universities, Arvada, Colorado.
Elizabeth BarkerNational Jewish Health, Denver, Colorado.
Margaret MrozNational Jewish Health, Denver, Colorado.
Anna E BarónDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Debashis GhoshDepartment of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Lisa MaierNational Jewish Health, Denver, Colorado.
Donna CragleOak Ridge Associated Universities, Oak Ridge, Tennessee.
Lee S NewmanCenter for Health, Work, and Environment, and Department of Environmental and Occupational Health and Department of Epidemiology, Colorado School of Public Health, University of Colorado, Anschutz Medical Campus, Aurora, Colorado.
Colorado School of Public Health · USNational Jewish Health · USOak Ridge Associated Universities · USUniversity of Colorado Cancer Center · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

backgroundThe beryllium lymphocyte proliferation test (BeLPT), has become the principal clinical test for detecting beryllium sensitization and chronic beryllium disease. Uninterpretable BeLPT results can occur in a small but significant proportion of tests from poor lymphocyte growth (PG) or over proliferation of lymphocytes (OP). The clinical and laboratory causes of uninterpretable results are not known.

methodsBeLPT data from the US Department of Energy-supported Former Worker Screening Program were analyzed for a 10-year period. Drivers of uninterpretable BeLPTs were investigated using multivariable models and classification techniques.

resultsThree participant attributes were significantly associated with PG, while OP showed no significant associations. Serum lot for the lymphocyte growth medium accounted for 21% of the variation in PG and 16% in OP.

conclusionSerum lots influence the likelihood of having uninterpretable BeLPT. To better understand uninterpretable results and possibly reduce their occurrence, additional laboratory-related factors should be addressed.

Indexed as

Clinical Laboratory TechniquesAgedBerylliosisBerylliumCase-Control StudiesCell ProliferationFemaleHumansLinear ModelsLymphocytesMaleMass ScreeningMiddle AgedMultivariate AnalysisOccupational ExposureUnited StatesBerylliumBeLPTBeSCBDchronic beryllium diseaselymphocyte proliferation

Identifiers

PMID29574954
PMCPMC6918945
OpenAlexW2793243231

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.