Evidence map›Paper›PMID 29574732›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2018

Commentary: Biological embedding of childhood adversity: where do we go from here? A reflection on Koss and Gunnar (2018).

Andrea Danese

Abstract readComment
PubMed Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Andrea DaneseSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The review by Koss & Gunna provides a scholarly overview of the role of the hypothalamic-pituitary-adrenal (HPA) axis in mediating the association between childhood adversity and psychopathology. Through their insightful observations, the authors craft a rich framework to critically appraise the current evidence and inform future research in this area. Overall, the review calls for a new generation of studies testing biological embedding hypotheses with greater attention to design, measurement, statistical models, and translational approaches. These new studies are much needed. By uncovering the causal pathways underlying the biological embedding of childhood adversity, we can gain important new tools to prevent the most impairing forms of psychopathology among the most vulnerable individuals in society.

Indexed as

Pituitary-Adrenal SystemPsychopathologyChildHumansHypothalamo-Hypophyseal SystemResearchAdversity

Identifiers

PMID29574732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.