Evidence map›Paper›PMID 29574607›Full record

ArticleEuropean journal of nutrition2019

The effect of bovine colostrum supplementation on intestinal injury and circulating intestinal bacterial DNA following exercise in the heat.

Daniel S March, Arwel W Jones, Rhys Thatcher, Glen Davison

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 7 pooled it
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 7 syntheses or guidelines pooled it, 46 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Daniel S MarchDepartment of Infection, Immunity and Inflammation, College of Life Sciences, University of Leicester, Leicester, UK.
Arwel W JonesLincoln Institute for Health, University of Lincoln, Lincoln, UK.
Rhys ThatcherInstitute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth, UK.
Glen DavisonEndurance Research Group, School of Sport and Exercise Sciences, University of Kent, Medway Campus, Chatham Maritime, ME4 4AG, UK. G.Davison@kent.ac.uk.ORCID http://orcid.org/0000-0003-4340-0074
Aberystwyth University · GBMedway School of Pharmacy · GBUniversity of Leicester · GBUniversity of Lincoln · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeExercise-induced changes in intestinal permeability are exacerbated in the heat. The aim of this study was to determine the effect of 14 days of bovine colostrum (Col) supplementation on intestinal cell damage (plasma intestinal fatty acid-binding protein, I-FABP) and bacterial translocation (plasma bacterial DNA) following exercise in the heat.

methodsIn a double-blind, placebo-controlled, crossover design, 12 males completed two experimental arms (14 days of 20 g/day supplementation with Col or placebo, Plac) consisting of 60 min treadmill running at 70% maximal aerobic capacity (30 °C, 60% relative humidity). Blood samples were collected pre-exercise (Pre-Ex), post-exercise (Post-Ex) and 1 h post-exercise (1 h Post-Ex) to determine plasma I-FABP concentration, and bacterial DNA (for an abundant gut species, Bacteroides).

resultsTwo-way repeated measures ANOVA revealed an arm × time interaction for I-FABP (P = 0.005, with greater Post-Ex increase in Plac than Col, P = 0.01: Plac 407 ± 194% of Pre-Ex vs Col, 311 ± 134%) and 1 h Post-Ex (P = 0.036: Plac 265 ± 80% of Pre-Ex vs Col, 229 ± 56%). There was no interaction (P = 0.904) but there was a main effect of arm (P = 0.046) for plasma Bacteroides/total bacterial DNA, with lower overall levels evident in Col.

conclusionThis is the first investigation to demonstrate that Col can be effective at reducing intestinal injury following exercise in the heat, but exercise responses (temporal pattern) of bacterial DNA were not influenced by Col (although overall levels may be lower).

Indexed as

ColostrumDietary SupplementsHot TemperatureRunningAdultAnimalsBacterial TranslocationCattleCell-Free Nucleic AcidsCross-Over StudiesDouble-Blind MethodFatty Acid-Binding ProteinsHumansHumidityIntestinesMaleCell-Free Nucleic AcidsFatty Acid-Binding ProteinsBacterial translocationCellular injuryCore temperatureEnvironmentIntestinal fatty acid-binding proteinIntestinal permeabilityStrenuous exercise

Identifiers

PMID29574607
PMCPMC6561991
OpenAlexW2792365522

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.