Evidence map›Paper›PMID 29574556›Full record

Trial reportJournal of neurology2018

Fatigue, as measured using the Modified Fatigue Impact Scale, is a predictor of processing speed improvement induced by exercise in patients with multiple sclerosis: data from a randomized controlled trial.

Giancarlo Coghe, Federica Corona, Elisabetta Marongiu, Giuseppe Fenu, Jessica Frau, Lorena Lorefice, Antonio Crisafulli, Manuela Galli, Alberto Concu, Maria Giovanna Marrosu and 2 more

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Observational
  5. Observational
  6. Article
  7. Article
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  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Giancarlo CogheDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy. gccoghe@gmail.com.ORCID http://orcid.org/0000-0002-3796-3279
Federica CoronaDepartment of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Elisabetta MarongiuSports Physiology Lab, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Giuseppe FenuDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy.
Jessica FrauDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy.
Lorena LoreficeDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy.
Antonio CrisafulliSports Physiology Lab, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Manuela GalliDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milan, Italy.
Alberto ConcuSports Physiology Lab, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Maria Giovanna MarrosuDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy.
Massimiliano PauDepartment of Mechanical, Chemical and Materials Engineering, University of Cagliari, Cagliari, Italy.
Eleonora CoccoDepartment of Medical Sciences and Public Health, Multiple Sclerosis Center, University of Cagliari, Cagliari, Italy.
University of Cagliari · ITPolitecnico di Milano · IT

Funding

regione sardegna grant CRP-49712 "Adapted Physical Activity in Multiple Sclerosis in Sardinia"regione sardegna L.R. 7/2007
6 · The paper itself

Abstract

backgroundFew studies have evaluated the impact of physical activity (PA) on cognition and fatigue, and none have considered the effects of PA on the relationship between cognition and fatigue.

objectivesWe evaluated the effect of PA in people with multiple sclerosis (pwMS) in a 6-month-long single-blind randomized controlled trial. We focused on the impact of exercise on cognition, fatigue, and the relationship between cognition and fatigue.

methodsWe recruited pwMS, who were then randomly assigned 1:1 to either a PA protocol group or a control group (CG). All patients underwent assessments using the Brief International Cognitive Assessment for Multiple Sclerosis including symbol digit modality test (SDMT), Berg Balance Scale (BBS), gait analysis, 6-Minute Walk Test, Timed Up and Go (TUG) test, and the Modified Fatigue Impact Scale (MFIS) at the beginning of the study (T0), at the end of the study (EOS) 24 weeks after T0, and at 24 weeks following the EOS (FU).

resultsA Wilcoxon test revealed a significant effect of exercise in the PA group, but not in the CG. Significant differences between T0 and EOS were found in the spatiotemporal parameters of gait, and performance on the SDMT, TUG, BBS, and MFIS. These differences were also present during the FU period. A regression model revealed that the baseline MFIS score predicted processing speed improvement (R

conclusionPA affects multiple aspects of the pathology in pwMS. Patients with greater fatigue must not be discouraged from exercise, as they may greatly benefit from PA. Specifically, PA was shown to improve information processing speed.

Indexed as

Exercise TherapyMental ProcessesAdultExerciseExercise TestFatigueFemaleGaitHumansMaleMiddle AgedMultiple Sclerosis, Relapsing-RemittingNeuropsychological TestsPostural BalancePrognosisSeverity of Illness IndexFatigueMFISMultiple sclerosisPhysical activityProcessing speed

Identifiers

PMID29574556
OpenAlexW2793601497

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.