Evidence map›Paper›PMID 29574550›Full record

ReviewCurrent cardiology reports2018

Light-Sheet Imaging to Elucidate Cardiovascular Injury and Repair.

Yichen Ding, Juhyun Lee, Jeffrey J Hsu, Chih-Chiang Chang, Kyung In Baek, Sara Ranjbarvaziri, Reza Ardehali, René R Sevag Packard, Tzung K Hsiai

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current cardiology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Emerging Light-Sheet Fluorescence Microscopy for Cardiac Vascular Imaging in Zebrafish.Current treatment options in cardiovascular medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yichen DingDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Juhyun LeeDepartment of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Jeffrey J HsuDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Chih-Chiang ChangDepartment of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Kyung In BaekDepartment of Bioengineering, University of California, Los Angeles, CA, 90095, USA.
Sara RanjbarvaziriDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Reza ArdehaliDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
René R Sevag PackardDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA.
Tzung K HsiaiDepartment of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 90095, USA. Thsiai@mednet.ucla.edu.

Funding

Linking Spatial Variations Shear Stress-Oxidative StressR01HL083015 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K · 2006 to 2015
$3.9M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Micro-Sensors to Study Electrical and Mechanical Coupling of Injured MyocardiumR01HL111437 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HSIAI, TZUNG K, XU, XIAOLEI · 2012 to 2020
$3.1M
NHLBI NIH HHS R01 HL083015NHLBI NIH HHS R01 HL111437NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727
6 · The paper itself

Abstract

purpose of reviewReal-time 3-dimensional (3-D) imaging of cardiovascular injury and regeneration remains challenging. We introduced a multi-scale imaging strategy that uses light-sheet illumination to enable applications of cardiovascular injury and repair in models ranging from zebrafish to rodent hearts. RECENT

findingsLight-sheet imaging enables rapid data acquisition with high spatiotemporal resolution and with minimal photo-bleaching or photo-toxicity. We demonstrated the capacity of this novel light-sheet approach for scanning a region of interest with specific fluorescence contrast, thereby providing axial and temporal resolution at the cellular level without stitching image columns or pivoting illumination beams during one-time imaging. This cutting-edge imaging technique allows for elucidating the differentiation of stem cells in cardiac regeneration, providing an entry point to discover novel micro-circulation phenomenon with clinical significance for injury and repair. These findings demonstrate the multi-scale applications of this novel light-sheet imaging strategy to advance research in cardiovascular development and regeneration.

Indexed as

Image Processing, Computer-AssistedImaging, Three-DimensionalAnimalsCardiovascular DiseasesHeart InjuriesMicroscopy, FluorescenceModels, AnimalModels, CardiovascularMyocardiumRegenerationRodentiaZebrafishCardiovascular injuryDoxorubicinLight-sheet imagingRegeneration

Identifiers

PMID29574550
PMCPMC5987244

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.