Evidence map›Paper›PMID 29574523›Full record

ArticleSurgery today2018

Alcohol consumption and early-onset risk of colorectal cancer in Japanese patients with Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.

Masashi Miguchi, Takao Hinoi, Kohji Tanakaya, Tatsuro Yamaguchi, Yoichi Furukawa, Teruhiko Yoshida, Kazuo Tamura, Kokichi Sugano, Chikashi Ishioka, Nagahide Matsubara and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Surgery today, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 15 institutions in 1 country.

Masashi MiguchiDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, 7348551, Hiroshima, Japan.
Takao HinoiDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi Minami-ku, 7348551, Hiroshima, Japan. thinoi@hiroshima-u.ac.jp.
Kohji TanakayaDepartment of Surgery, Iwakuni Clinical Center, Yamaguchi, Japan.
Tatsuro YamaguchiDepartment of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
Yoichi FurukawaDivision of Clinical Genome Research, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Teruhiko YoshidaDivision of Genetics, National Cancer Center Research Institute, Tokyo, Japan.
Kazuo TamuraMajor in Science, Graduate School of Science and Engineering Research, Kinki University, Higashiosaka, Japan.
Kokichi SuganoOncogene Research Unit/Cancer Prevention Unit, Tochigi Cancer Center Research Institute, Utsunomiya, Japan.
Chikashi IshiokaDepartment of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Nagahide MatsubaraDepartment of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Naohiro TomitaDepartment of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Masami AraiClinical Genetic Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
Hideki IshikawaDepartment of Molecular-Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Keiji HirataDepartment of Surgery 1, University of Occupational and Environmental Health, Kitakyushu, Japan.
Yoshihisa SaidaDepartment of Surgery, Toho University Ohashi Medical Center, Tokyo, Japan.
Hideyuki IshidaDepartment of Digestive Tract and General Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan.
Kenichi SugiharaTokyo Medical and Dental University, Tokyo, Japan.
Hiroshima University · JPHyogo Medical University · JPIwakuni Medical Center · JPJapanese Foundation For Cancer Research · JPKindai University · JPKyoto Prefectural University of Medicine · JPNational Cancer Centre Japan · JPSocial Insurance Saitama Chuo Hospital · JPThe University of Tokyo · JPTochigi Cancer Center · JPTohoku University · JPToho University Ohashi Medical Center · JPTokyo Medical and Dental University · JPTokyo Metropolitan Komagome Hospital · JPUniversity of Occupational and Environmental Health Japan · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted this study to establish whether drinking alcohol alters the risk of early-onset colorectal cancer (CRC) in Japanese patients with Lynch syndrome (LS). The subjects were 66 LS patients with pathogenic mutation of mismatch repair genes (MLH1, MSH2, and MSH6) from the nationwide Japanese retrospective multicenter study. Cox proportional hazards modeling was used to investigate the factors correlating with early-onset CRC diagnosis, using clinical data such as gender, tobacco use, alcohol consumption, body mass index, gene mutation (MLH1, MSH2 vs MSH6), and family cancer history. Alcohol was significantly correlated with an increased risk of early-onset CRC [HR 2.44, 95% CI 1.13-5.16 (p = 0.02)], but tobacco use was not [HR 0.8, 95%CI 0.38-1.62 (p = 0.53)]. These findings suggest that alcohol consumption is correlated with an earlier onset of CRC in Japanese patients with LS.

Indexed as

AdultAgedAge of OnsetAlcohol DrinkingAsian PeopleColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisCross-Sectional StudiesDNA-Binding ProteinsFemaleHumansJapanMaleMedical OncologyMiddle AgedMulticenter Studies as TopicDNA-Binding ProteinsG-T mismatch-binding proteinMLH1 protein, humanMSH2 protein, humanMutL Protein Homolog 1MutS Homolog 2 ProteinAlcoholColorectal cancerLynch syndrome

Identifiers

PMID29574523
OpenAlexW2792007810

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.