SynthesisOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2018
Sleep duration and the risk of osteoporosis among middle-aged and elderly adults: a dose-response meta-analysis.
Synthesis in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association Between Sleep Duration and Low Bone Mineral Density and Osteoporosis: A Systematic Review and Meta-analysis.Calcified tissue international · 2024Pooled it
- Sleep duration and health outcomes: an umbrella review.Sleep & breathing = Schlaf & Atmung · 2022Pooled it
- Association between genetic polymorphisms and osteonecrosis in steroid treatment populations: a detailed stratified and dose-response meta-analysis.Bioscience reports · 2019Pooled it
- Expert consensus on osteoporosis risk management in patients with sleep disorders.Bone research · 2026Review
- Impact of sleep duration on bone mineral density and osteoporosis risk: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Review
- The risk of osteoporosis in COPD: An analysis of sex differences and mediating effects based on NHANES.NPJ primary care respiratory medicine · 2026Article
- Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Association Between Sleep Quality and Geriatric Hip Fracture: A Prospective Comparative Study.Geriatric orthopaedic surgery & rehabilitation · 2026Article
- Association between sleep duration, sleep apnea risk, and osteoporosis in older adults: a cross-sectional study in elder care institutions in Taiwan.BMC geriatrics · 2025Article
- Self-reported sleep disturbances are associated with osteoporosis: multivariable-adjusted and Mendelian randomization analyses in UK Biobank.JBMR plus · 2025Article
- Identifying modifiable factors and their causal effects on osteoporosis risk.Scientific reports · 2025Article
- Association between sleep duration and hip fracture risk among the older adults: a cross-sectional study based on the NHANES.BMC musculoskeletal disorders · 2025Article
- Poor sleep and high rheumatoid arthritis risk: Evidence from large UK Biobank cohort.PloS one · 2025Article
- 24-hour activity composition is associated with lower fall and fracture risk in older men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Association of combined healthy lifestyle factors with incident osteoporosis in patients with and without type 2 diabetes.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024Article
- Association of nocturnal sleep duration and sleep midpoint with osteoporosis risk in rural adults: a large-scale cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2023Article
- Fall Risk in Elderly with Insomnia in Western Romania-A Retrospective Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2023Article
- Association of Self-Reported Sleep Characteristics and Hip Fracture: Observational and Mendelian Randomization Studies.Healthcare (Basel, Switzerland) · 2023Article
- Evaluation of the Quality of Life and the Quality of Sleep of postmenopausal osteoporotic women, without evidence of an osteoporotic fracture, who attended an outpatient DXA scan service.Journal of musculoskeletal & neuronal interactions · 2023Article
- Trends and disparities in sleep quality and duration in older adults in China from 2008 to 2018: A national observational study.Frontiers in public health · 2023Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
It remains unclear how many hours of sleep are associated with the lowest risk of osteoporosis. This meta-analysis was performed to assess the dose-response relationship between sleep duration and risk of osteoporosis. PubMed and Web of Science were searched from inception to December 3, 2017, supplemented by manual searches of the bibliographies of retrieved articles. Data were pooled using fixed- and random-effects models. Restricted cubic spline analysis with four knots was used to model the sleep duration and osteoporosis association. Four cross-sectional studies with eight records were eligible for inclusion in the meta-analysis. A U-shaped dose-response relationship was observed between sleep duration and risk of osteoporosis, with the lowest risk observed at a sleep duration category of 8-9 h per day. Compared with 8-h sleep duration per day, the pooled odds ratio for osteoporosis were 1.03 (95% CI 1.01-1.06) for each 1-h reduction among individuals with shorter sleep duration and 1.01 (95% CI 1.00-1.02) for each 1-h increment among individuals with longer sleep duration. Our dose-response meta-analysis shows a U-shaped relationship between sleep duration and risk of osteoporosis, with the lowest osteoporosis risk at about 8 h per day of sleep duration. Both short and long sleep duration is associated with a significantly increased risk of osteoporosis in the middle-aged and elderly adults, appropriate sleep duration could help for delay or prevention of osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.