ReviewClinical autonomic research : official journal of the Clinical Autonomic Research Society2018
Ventilatory and cerebrovascular regulation and integration at high-altitude.
Review in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.
- Effects of long-term exposure to high altitude on brain structure in healthy people: an MRI-based systematic review and meta-analysis.Frontiers in psychiatry · 2023Pooled it
- Intermittent hypoxia interventions for inducing ventilatory acclimatization to high altitude?Experimental physiology · 2026Review
- Intracranial pressure physiology, monitoring and individualized management in the acute brain injured patient.Intensive care medicine · 2026Review
- Between-visit reproducibility of cerebrovascular and cardiovascular reactivity during the cold pressor test.American journal of physiology. Heart and circulatory physiology · 2026Article
- Exploratory analysis of high-altitude effects on brain morphology and myelination in native Tibetan infants.Translational pediatrics · 2026Article
- Brain strain: Blood flow and metabolism in environmental extremes.Experimental physiology · 2026Review
- Newborn brain development comparison of plateau and plain regions: insights from quantitative EEG.Pediatric research · 2026Article
- High-altitude hypoxic cues and cerebral ischemic tolerance: an evidence-graded translational framework for stroke research.Frontiers in neuroscience · 2026Review
- Born high, born fast: Does highland birth confer a pulmonary advantage for sea level endurance?Experimental physiology · 2025Review
- Smoking and High-Altitude Exposure Affect Intrinsic Neural Activity: A fMRI Study of Interactive Effects.Addiction biology · 2025Article
- Hemorrhage at high altitude: impact of sustained hypobaric hypoxia on cerebral blood flow, tissue oxygenation, and tolerance to simulated hemorrhage in humans.European journal of applied physiology · 2024Article
- [Cerebral oxygen metabolism and brain electrical activity of healthy full-term neonates in high-altitude areas: a multicenter clinical research protocol].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- A diffusion tensor imaging-based multidimensional study of brain structural changes after long-term high-altitude exposure and their relationships with cognitive function.Frontiers in physiology · 2024Article
- Cerebral blood flow and cerebrovascular reactivity are modified by maturational stage and exercise training status during youth.Experimental physiology · 2023Article
- Manipulation of iron status on cerebral blood flow at high altitude in lowlanders and adapted highlanders.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Combining hypoxia with thermal stimuli in humans: physiological responses and potential sex differences.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Review
- High-altitude cerebral edema manifesting as T2/FLAIR hyperintensity and microbleeds in the white matter on MRI brain.Radiology case reports · 2023Article
- Brain-aging related protein expression and imaging characteristics of mice exposed to chronic hypoxia at high altitude.Frontiers in aging neuroscience · 2023Article
- [Changes of myocardial calcium currents in rats with myocardial injury induced by running exercise during acute hypoxia].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Neuromuscular fatigability at high altitude: Lowlanders with acute and chronic exposure, and native highlanders.Acta physiologica (Oxford, England) · 2022Review
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4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Ascent to high-altitude elicits compensatory physiological adaptations in order to improve oxygenation throughout the body. The brain is particularly vulnerable to the hypoxemia of terrestrial altitude exposure. Herein we review the ventilatory and cerebrovascular changes at altitude and how they are both implicated in the maintenance of oxygen delivery to the brain. Further, the interdependence of ventilation and cerebral blood flow at altitude is discussed. Following the acute hypoxic ventilatory response, acclimatization leads to progressive increases in ventilation, and a partial mitigation of hypoxemia. Simultaneously, cerebral blood flow increases during initial exposure to altitude when hypoxemia is the greatest. Following ventilatory acclimatization to altitude, and an increase in hemoglobin concentration-which both underscore improvements in arterial oxygen content over time at altitude-cerebral blood flow progressively decreases back to sea-level values. The complimentary nature of these responses (ventilatory, hematological and cerebral) lead to a tightly maintained cerebral oxygen delivery while at altitude. Despite this general maintenance of global cerebral oxygen delivery, the manner in which this occurs reflects integration of these physiological responses. Indeed, ventilation directly influences cerebral blood flow by determining the prevailing blood gas and acid/base stimuli at altitude, but cerebral blood flow may also influence ventilation by altering central chemoreceptor stimulation via central CO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.