ArticleMolecular diversity2018
Synthesis and antimicrobial evaluation of novel 1,2,4-triazole thioether derivatives bearing a quinazoline moiety.
Article in Molecular diversity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Novel carbazole-triazole-thioether conjugates as multifunctional antimicrobial agents against phytopathogen.Molecular diversity · 2026Article
- Design, Synthesis, and Antimicrobial Evaluation of Novel 6-Fluoroquinazolinone Derivatives Incorporating Thioether and Ethyl Ester Pharmacophores.Chemistry & biodiversity · 2026Article
- Rational design, synthesis, and antimicrobial evaluation of novel 1,2,4-trizaole-substituted 1,3,4-oxadiazole derivatives with a dual thioether moiety.Molecular diversity · 2025Article
- Synthesis, antifungal activity and mechanism of action of novel chalcone derivatives containing 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole.Molecular diversity · 2024Article
- Novel 2-Sulfanylquinazolin-4(3Molecules (Basel, Switzerland) · 2023Article
- Urea-thiazole/benzothiazole hybrids with a triazole linker: synthesis, antimicrobial potential, pharmacokinetic profile and in silico mechanistic studies.Molecular diversity · 2022Article
- Article
- Synthesis, X-ray Structure, Hirshfeld, DFT and Biological Studies on a Quinazolinone-Nitrate Complex.Molecules (Basel, Switzerland) · 2022Article
- Recent advances in the pharmacological diversification of quinazoline/quinazolinone hybrids.RSC advances · 2020Review
- A MEDT computational study of the mechanism, reactivity and selectivity of non-polar [3+2] cycloaddition between quinazoline-3-oxide and methyl 3-methoxyacrylate.Journal of molecular modeling · 2020Article
- Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens.Molecular diversity · 2019Article
- Design and synthesis of novel 2-(6-thioxo-1,3,5-thiadiazinan-3-yl)-N'-phenylacethydrazide derivatives as potential fungicides.Molecular diversity · 2019Article
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3 authors.
Funding
Abstract
A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1H-1,2,4-triazol-5-amine derivatives (7a-7r) were designed and synthesized based on a pharmacophore hybrid approach, and screened for their antibacterial and antifungal activities in vitro. All the target compounds were fully characterized through [Formula: see text]H NMR, [Formula: see text]C NMR and HRMS spectra. Among them, the structure of compound 7b was further confirmed via single-crystal X-ray diffraction analysis. The obtained results indicated that several target compounds demonstrated notable inhibition activities against tested phytopathogenic bacteria, using a turbidimetric method. For example, compounds 7d, 7g and 7i exhibited EC[Formula: see text] (half-maximal effective concentration) values of 46.9, 47.8 and 43.2 µg/mL, respectively, against the bacterium Xanthomonas axonopodis pv. citri (Xac), which were more potent than commercial agrobactericide Bismerthiazol (56.9 µg/mL). Moreover, EC[Formula: see text] values of compounds 7a and 7h were found to be 81.6 and 93.1 µg/mL, respectively, against the bacterium Ralstonia solanacearum (Rs), being over twofold more active than commercial agrobactericide Thiodiazole-copper (189.6 µg/mL). Finally, some compounds displayed a certain degree of inhibition activity against tested phytopathogenic fungi at 50 µg/mL.
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