Evidence map›Paper›PMID 29574462›Full record

ArticleJournal of the American Heart Association2018

Remote Limb Ischemic Preconditioning Attenuates Cerebrovascular Depression During Sinusoidal Galvanic Vestibular Stimulation via α

Devin W McBride, Cesar Reis, John H Zhang, Richard Applegate, Jiping Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Devin W McBrideDepartment of Physiology & Pharmacology, Loma Linda University, Loma Linda, CA.
Cesar ReisDepartment of Anesthesiology, Loma Linda University, Loma Linda, CA.
John H ZhangDepartment of Physiology & Pharmacology, Loma Linda University, Loma Linda, CA.
Richard ApplegateDepartment of Anesthesiology, Loma Linda University, Loma Linda, CA.
Jiping TangDepartment of Physiology & Pharmacology, Loma Linda University, Loma Linda, CA jtang@llu.edu.
Loma Linda University · US

Funding

Neurovascular Protection for Early Brain Injury after SAHR01NS081740 · NINDS · LOMA LINDA UNIVERSITY · PI ZHANG, JOHN H · 2013 to 2017
$1.6M
NINDS NIH HHS R01 NS081740
6 · The paper itself

Abstract

backgroundVasovagal syncope (VVS) is characterized by hypotension and bradycardia followed by lowering of cerebral blood flow. Remote limb ischemic preconditioning (RIPC) is well documented to provide cardio- and neuroprotection as well as to improve cerebral blood flow. We hypothesized that RIPC will provide protection against VVS-induced hypotension, bradycardia, and cerebral hypoperfusion. Second, because endothelial nitric oxide synthase has been reported as a mediator of cerebral blood flow control, we hypothesized that the mechanism by which RIPC primes the vasculature against VVS is via the α METHODS AND

resultsWe utilized sinusoidal galvanic vestibular stimulation in rats as a model of VVS. RIPC attenuated the lowerings of mean arterial pressure, heart rate, and cerebral blood flow caused by sinusoidal galvanic vestibular stimulation, as well as improving behavior during, and recovery after, stimulation. RIPC induced elevated serum norepinephrine, increased expression of brain α

conclusionsTaken together, this study indicates that RIPC may be a potential therapy that can prevent VVS pathophysiology, decrease syncopal episodes, and reduce the injuries associated with syncopal falls. Furthermore, the α

Indexed as

Cerebrovascular CirculationAge FactorsAnimalsArterial PressureBradycardiaDisease Models, AnimalElectric StimulationFemaleHeart RateHindlimbHypotensionIschemic PreconditioningMaleNitric Oxide Synthase Type IIINorepinephrine Plasma Membrane Transport ProteinsProtein Kinase C-epsilonAdra1a protein, ratNitric Oxide Synthase Type IIINorepinephrine Plasma Membrane Transport ProteinsNos3 protein, ratPrkce protein, ratProtein Kinase C-epsilonReceptors, Adrenergic, alpha-1Slc6a2 protein, ratcatecholamineischemiapreconditioningsyncope

Identifiers

PMID29574462
PMCPMC5907579
OpenAlexW2793728657

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.