Evidence map›Paper›PMID 29574439›Full record

ArticleBMJ open2018

Randomised controlled trial of exercise to prevent shoulder problems in women undergoing breast cancer treatment: study protocol for the prevention of shoulder problems trial (UK PROSPER).

Julie Bruce, Esther Williamson, Clare Lait, Helen Richmond, Lauren Betteley, Ranjit Lall, Stavros Petrou, Sophie Rees, Emma J Withers, Sarah E Lamb and 2 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Julie BruceDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.ORCID 0000-0002-8462-7999
Esther WilliamsonNuffield Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford, Windmill Road, Oxford, UK.
Clare LaitGloucestershire Care Services NHS Trust, Gloucester, UK.
Helen RichmondDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Lauren BetteleyDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Ranjit LallDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Stavros PetrouDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Sophie ReesDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Emma J WithersDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Sarah E LambDivision of Health Sciences, Warwick Clinical Trials Unit, University of Warwick, Coventry, UK.
Alastair M ThompsonDepartment of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
PROSPER Study Group
University of Warwick · GBNuffield Orthopaedic Centre · GBGloucestershire Health and Care NHS Foundation Trust · GBThe University of Texas MD Anderson Cancer Center · US

Funding

Department of Health HTA/13/84/10Medical Research Council G0501681Medical Research Council G0700452
6 · The paper itself

Abstract

Musculoskeletal shoulder problems are common after breast cancer treatment. Early postoperative exercises targeting the upper limb may improve shoulder function. This protocol describes a National Institute for Health Research-funded randomised controlled trial (RCT) to evaluate the clinical and cost-effectiveness of an early supervised structured exercise programme compared with usual care, for women at high risk of developing shoulder problems after breast cancer surgery.

methodsThis pragmatic two-armed, multicentre RCT is underway within secondary care in the UK. PRevention Of Shoulder ProblEms tRial (PROSPER) aims to recruit 350 women from approximately 15 UK centres with follow-up at 6 weeks, 6 and 12 months after randomisation. Recruitment processes and intervention development were optimised through qualitative research during a 6-month internal pilot phase. Participants are randomised to the PROSPER intervention or best practice usual care only. The PROSPER intervention is delivered by physiotherapists and incorporates three main components: shoulder-specific exercises targeting range of movement and strength; general physical activity and behavioural strategies to encourage adherence and support exercise behaviour. The primary outcome is upper arm function assessed using the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire at 12 months postrandomisation. Secondary outcomes include DASH subscales, acute and chronic pain, complications, health-related quality of life and healthcare resource use. We will interview a subsample of 20 participants to explore their experiences of the trial interventions. DISCUSSION: The PROSPER study is the first multicentre UK clinical trial to investigate the clinical and cost-effectiveness of supported exercise in the prevention of shoulder problems in high-risk women undergoing breast cancer surgery. The findings will inform future clinical practice and provide valuable insight into the role of physiotherapy-supported exercise in breast cancer rehabilitation. PROTOCOL VERSION: Version 2.1; dated 11 January 2017 TRIAL REGISTRATION NUMBER: ISRCTN35358984; Pre-results.

Indexed as

Breast NeoplasmsExercise TherapyMusculoskeletal DiseasesPostoperative ComplicationsShoulderBehavior TherapyCost-Benefit AnalysisFemaleHumansLinear ModelsMulticenter Studies as TopicPragmatic Clinical Trials as TopicQuality of LifeRandomized Controlled Trials as TopicResearch DesignSurveys and Questionnairesbreast surgeryclinical trialsrehabilitation medicine

Identifiers

PMID29574439
PMCPMC5875650
OpenAlexW2786567955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.