Evidence map›Paper›PMID 29574339›Full record

ArticleEnvironment international2018

Indoor black carbon of outdoor origin and oxidative stress biomarkers in patients with chronic obstructive pulmonary disease.

Stephanie T Grady, Petros Koutrakis, Jaime E Hart, Brent A Coull, Joel Schwartz, Francine Laden, Junfeng Jim Zhang, Jicheng Gong, Marilyn L Moy, Eric Garshick

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Association of PMRespiratory research · 2026
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  7. Implications of DNA damage in chronic lung disease.Frontiers in cell and developmental biology · 2024
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  8. Article
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  10. Review
  11. Determinants of indoor carbonaceous aerosols in homes in the Northeast United States.Journal of exposure science & environmental epidemiology · 2023
    Article
  12. Article
  13. Article
  14. The Effects and Pathogenesis of PM2.5 and Its Components on Chronic Obstructive Pulmonary Disease.International journal of chronic obstructive pulmonary disease · 2023
    Review
  15. Cold Climate Impact on Air-Pollution-Related Health Outcomes: A Scoping Review.International journal of environmental research and public health · 2022
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Stephanie T GradyResearch and Development Service, VA Boston Healthcare System, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: stephanie.grady@channing.harvard.edu.
Petros KoutrakisDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Jaime E HartChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Brent A CoullDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Joel SchwartzChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Francine LadenChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Junfeng Jim ZhangNicholas School of the Environment, Duke University, Durham, NC, USA.
Jicheng GongNicholas School of the Environment, Duke University, Durham, NC, USA; BIC-ESAT and SKL-ESPC, College of Environmental Sciences and Engineering, Peking University, Beijing, China.
Marilyn L MoyPulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA.
Eric GarshickPulmonary, Allergy, Sleep, and Critical Care Medicine, VA Boston Healthcare System and Harvard Medical School, Boston, MA, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USHarvard University · USDuke University · USPeking University · CN

Funding

COPD and Response to Traffic Related ParticlesR01ES019853 · NIEHS · HARVARD MEDICAL SCHOOL · PI GARSHICK, ERIC · 2012 to 2016
$3.1M
NIEHS NIH HHS R01 ES019853
6 · The paper itself

Abstract

objectivesWe assessed relationships between indoor black carbon (BC) exposure and urinary oxidative stress biomarkers, 8-hydroxy-2'-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), in participants with chronic obstructive pulmonary disease (COPD).

methodsEighty-two participants completed in-home air sampling for one week prior to providing urine samples up to four times in a year. Weekly indoor and daily outdoor concentrations were used to estimate indoor daily lags and moving averages. There were no reported in-home BC sources, thus indoor levels closely represented outdoor BC infiltration. Mixed effects regression models with a random intercept for each participant were used to assess relationships between indoor BC and 8-OHdG and MDA, adjusting for age, race, BMI, diabetes, heart disease, season, time of urine collection, urine creatinine, and outdoor humidity and temperature.

resultsThere were positive effects of BC on 8-OHdG and MDA, with the greatest effect the day before urine collection (6.9% increase; 95% CI 0.9-13.3%, per interquartile range: 0.22 μg/m

conclusionsWe found positive associations between BC exposure and 8-OHdG and MDA, in which associations with 8-OHdG were stronger in obese participants. These results suggest that exposure to low levels of traffic-related pollution results in lipid peroxidation and oxidative DNA damage in individuals with COPD.

Indexed as

Air PollutantsPulmonary Disease, Chronic ObstructiveSootBiomarkersCohort StudiesHumansOxidative StressAir PollutantsBiomarkersSootCOPDPollutionUrinary oxidative stress

Identifiers

PMID29574339
PMCPMC5970068
OpenAlexW2794200698

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.