Evidence map›Paper›PMID 29574034›Full record

ReviewNeuroImage2019

Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review.

Peiying Liu, Jill B De Vis, Hanzhang Lu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 176 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
176citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

176 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effects of candesartan on cerebral microvascular function in mild cognitive impairment: Results of two clinical trials.International journal of stroke : official journal of the International Stroke Society · 2023
    Pooled it
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  5. Reproducibility of cerebrovascular reactivity measurements: A systematic review of neuroimaging techniquesJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Pooled it
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  8. Article
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  11. Review
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  13. Cerebrovascular reactivity delay measured by blood oxygen level dependent magnetic resonance imaging and gas challenges: A systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  14. Observational
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116 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States. Electronic address: peiying.liu@jhu.edu.
Jill B De VisDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, United States; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, 21287, United States; F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, 21205, United States.

Funding

TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
Cognition and cerebrovascular function across the lifespanR01AG042753 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2013 to 2015
$841k
Advanced MRI methods to image vascular physiology with respiratory manipulationsR21NS095342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2016 to 2017
$476k
Development of techniques to map cerebrovascular reactivity with resting-state MRIR21NS100006 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LIU, PEIYING · 2017 to 2018
$450k
ELECTROPHYSIOLOGICAL PROPERTIES OF AMYGDALAF32NS010006 · NINDS · LAVAL UNIVERSITY · PI LANG, ERIC J · 1995 to 1997
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NIA NIH HHS R01 AG042753NIA NIH HHS R01 AG047972NIBIB NIH HHS P41 EB015909NIMH NIH HHS R01 MH084021NINDS NIH HHS F32 NS010006NINDS NIH HHS R21 NS095342NINDS NIH HHS R21 NS100006
6 · The paper itself

Abstract

Cerebrovascular reactivity (CVR) is an indicator of cerebrovascular reserve and provides important information about vascular health in a range of brain conditions and diseases. Unlike steady-state vascular parameters, such as cerebral blood flow (CBF) and cerebral blood volume (CBV), CVR measures the ability of cerebral vessels to dilate or constrict in response to challenges or maneuvers. Therefore, CVR mapping requires a physiological challenge while monitoring the corresponding hemodynamic changes in the brain. The present review primarily focuses on methods that use CO2 inhalation as a physiological challenge while monitoring changes in hemodynamic MRI signals. CO2 inhalation has been increasingly used in CVR mapping in recent literature due to its potency in causing vasodilation, rapid onset and cessation of the effect, as well as advances in MRI-compatible gas delivery apparatus. In this review, we first discuss the physiological basis of CVR mapping using CO2 inhalation. We then review the methodological aspects of CVR mapping, including gas delivery apparatus, the timing paradigm of the breathing challenge, the MRI imaging sequence, and data analysis. In addition, we review alternative approaches for CVR mapping that do not require CO2 inhalation.

Indexed as

Brain MappingCarbon DioxideCerebral CortexHemodynamicsHumansHypercapniaMagnetic Resonance ImagingRespirationVasodilationCarbon DioxideArterial spin labelingBOLDCarbon dioxideCerebrovascular reactivityCerebrovascular reserveEnd-tidal CO2HypercapniaPhase-contrast MRI

Identifiers

PMID29574034
PMCPMC6150860

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.