Evidence map›Paper›PMID 29573947›Full record

ArticleTrends in endocrinology and metabolism: TEM2018

Blocking Bone Loss with l-BAIBA.

Mark W Hamrick, Meghan E McGee-Lawrence

Abstract readComment
PubMed Publisher
In one paragraph

Article in Trends in endocrinology and metabolism: TEM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Exerkines and myokines in aging sarcopenia.Frontiers in endocrinology · 2025
    Review
  3. Review
  4. Review
  5. Review
  6. Effects of Muscles on Bone Metabolism-with a Focus on Myokines.Annals of geriatric medicine and research · 2022
    Article
  7. [Research progress on mechanism of myokines regulating bone tissue cells].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Review
  8. Bone and Muscle Crosstalk in Aging.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mark W HamrickMedical College of Georgia, Augusta University, Augusta, GA 30912, USA. Electronic address: mhamrick@augusta.edu.
Meghan E McGee-LawrenceMedical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteocytes are cells nested within the mineralized bone matrix that play a key role in maintaining bone mass. New findings in Cell Reports show that β-aminoisobutyric acid (l-BAIBA), a metabolite secreted from muscle, promotes osteocyte survival under oxidative stress. This discovery reveals a novel mechanism linking muscle activity to skeletal health.

Indexed as

Aminoisobutyric AcidsOsteocytesMuscles3-aminoisobutyric acidAminoisobutyric Acids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.