ArticleAcademic radiology2018
Differentiation of Benign and Malignant Thyroid Nodules by Using Comb-push Ultrasound Shear Elastography: A Preliminary Two-plane View Study.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Accuracy of Ultrasound Diagnosis of Benign and Malignant Thyroid Nodules: A Systematic Review and Meta-Analysis.International journal of clinical practice · 2022Pooled it
- Deep learning-based classification of thyroid nodules using uncertainty-aware multi-modal ultrasound imaging.Scientific reports · 2026Article
- Deep learning based motion correction in ultrasound microvessel imaging approach improves thyroid nodule classification.Scientific reports · 2025Article
- The mechanopathology of the tumor microenvironment: detection techniques, molecular mechanisms and therapeutic opportunities.Frontiers in cell and developmental biology · 2025Review
- Can pre-operative ultrasound elastography predict aggressive features of solitary papillary thyroid carcinoma?The British journal of radiology · 2023Article
- Article
- Diagnostic performance of artificial intelligence-based computer-aided diagnosis system in longitudinal and transverse ultrasonic views for differentiating thyroid nodules.Frontiers in endocrinology · 2023Article
- Added value of mass characteristic frequency to 2-D shear wave elastography for differentiation of benign and malignant thyroid nodules.Ultrasound in medicine & biology · 2022Article
- Efficacy of Differential Diagnosis of Thyroid Nodules by Shear Wave Elastography-the Stiffness Map.Journal of the Endocrine Society · 2021Article
- The Advance of Magnetic Resonance Elastography in Tumor Diagnosis.Frontiers in oncology · 2021Review
- Ultrasound elastography using a regularized modified error in constitutive equations (MECE) approach: a comprehensive phantom study.Physics in medicine and biology · 2020Article
- Shear wave elasticity by tracing total nodule showed high reproducibility and concordance with fibrosis in thyroid cancer.BMC cancer · 2020Article
- Gap-filling method for suppressing grating lobes in ultrasound imaging: Experimental study with deep-learning approach.IEEE access : practical innovations, open solutions · 2020Article
- Segmentation and Diagnosis of Papillary Thyroid Carcinomas Based on Generalized Clustering Algorithm in Ultrasound Elastography.Journal of medical systems · 2019Article
- Update on thyroid ultrasound: a narrative review from diagnostic criteria to artificial intelligence techniques.Chinese medical journal · 2019Article
- Ultrasound elastography of the thyroid: principles and current status.Ultrasonography (Seoul, Korea) · 2019Article
- Oncocytes in Thyroid Aspirates-Implications of Clinical Parameters and Cytologic Diagnosis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialeArticle
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12 authors at 1 institution in 1 country.
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Abstract
RATIONALE AND
objectivesLow specificity of traditional ultrasound in differentiating benign from malignant thyroid nodules leads to a great number of unnecessary (ie, benign) fine-needle aspiration biopsies that causes a significant financial and physical burden to the patients. Ultrasound shear wave elastography is a technology capable of providing additional information related to the stiffness of tissues. In this study, quantitative stiffness values acquired by ultrasound shear wave elastography in two different imaging planes were evaluated for the prediction of malignancy in thyroid nodules. In addition, the association of elasticity measurements with sonographic characteristics of thyroid gland and nodules is presented. MATERIALS AND
methodsA total number of 155 patients (106 female and 49 male) (average age 57.48 ± 14.44 years) with 173 thyroid nodules (average size 24.89 ± 15.41 mm, range 5-68 mm) scheduled for fine-needle aspiration biopsy were recruited from March 2015 to May 2017. Comb-push shear elastography imaging was performed at longitudinal and transverse anatomic planes. Mean (E
resultsMeasurements at longitudinal view were statistically significantly higher than measurements at transverse view. Nodules with calcifications were associated with increased elasticity, and nodules with a vascular component or within an enlarged thyroid gland (goiter) were associated with a lower elasticity value. Receiver operating characteristic curve analysis was performed for E
conclusionsThe elastic properties of thyroid nodules showed promise to be a good discriminator between malignant and benign nodules (P < .0001). However, probe orientation and internal features such as calcifications, vascular component, and goiter may influence the final elastography measurements. A larger number of malignant nodules need to be studied to further validate our results.
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