Evidence map›Paper›PMID 29573910›Full record

ArticleBioorganic & medicinal chemistry letters2018

Synthesis and investigations into the anticancer and antibacterial activity studies of β-carboline chalcones and their bromide salts.

P O Venkataramana Reddy, M Hridhay, Kumar Nikhil, Shahid Khan, P N Jha, Kavita Shah, Dalip Kumar

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Chalcones as Emerging Antibacterial Scaffolds: A Mini Review.Mini reviews in medicinal chemistry · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. 3-(1,2,3-Triazol-4-yl)-β-Carbolines and 3-(1Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Chalcone: A Promising Bioactive Scaffold in Medicinal Chemistry.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. The Synergy of Ciprofloxacin and Carvedilol againstMolecules (Basel, Switzerland) · 2019
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

P O Venkataramana ReddyDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India.
M HridhayDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India.
Kumar NikhilPurdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States.
Shahid KhanDepartment of Biological Sciences, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India.
P N JhaDepartment of Biological Sciences, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India.
Kavita ShahPurdue University Center for Cancer Research, Purdue University, West Lafayette, IN 47907, United States. Electronic address: shah23@purdue.edu.
Dalip KumarDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333 031, Rajasthan, India. Electronic address: dalipk@pilani.bits-pilani.ac.in.

Funding

Chemical Genetic Dissection of Aurora A in Promoting EMT and Stem Cells PhenotypeR03CA166912 · NCI · PURDUE UNIVERSITY · PI SHAH, KAVITA · 2013 to 2014
$152k
NCI NIH HHS R03 CA166912
6 · The paper itself

Abstract

A series of sixteen β-carbolines, bearing chalcone moiety at C-1 position, were prepared from easily accessible 1-acetyl-β-carboline and various aldehydes under basic conditions followed by N

Indexed as

Anti-Bacterial AgentsAntineoplastic AgentsApoptosisBacillus subtilisBromidesCarbolinesCell Line, TumorChalconesChloramphenicolDoxorubicinDrug DesignDrug Screening Assays, AntitumorEnterobacter cloacaeEscherichia coliHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntineoplastic AgentsBromidesCarbolinesChalconesChloramphenicolDoxorubicinSaltsAntibacterial activityAnticancer activityApoptosisβ-Carboline chalconesβ-Carbolinium chalcone bromides

Identifiers

PMID29573910
PMCPMC6423518

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.