ArticleEnvironment international2018
Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.
Article in Environment international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- Influence of theInternational journal of environmental research and public health · 2026Article
- Statement on the findings presented in the Toxicological Profile for Mercury issued by the US ATSDR.EFSA journal. European Food Safety Authority · 2026Article
- Relationship between susceptibility to neurodegenerative diseases and genetic factors in populations exposed to mercury in Medellín, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Genetic Modulation of Mercury Exposure on Perinatal and Birth Outcomes: A Systematic Review and Meta-Analysis of Gene-Environment Interactions.Journal of xenobiotics · 2026Review
- Association Between Hair Trace Element Content and Children's Growth and Development: Protocol for a Cross-Sectional Surveillance Study.JMIR research protocols · 2025Article
- Trace Metal and Metalloid Profiles in Hair Samples from Children in the Oil-Producing Region of Kazakhstan.Toxics · 2025Article
- Transcriptomic analysis identifies muscle-specific mitochondrial and vesicular transport genes as methylmercury toxicity targets in a Drosophila model of congenital Minamata disease.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- TheToxics · 2024Article
- Intestinal microbiota protects against methylmercury-induced neurotoxicity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview.Toxics · 2024Review
- KEAP1 polymorphisms and neurodevelopmental outcomes in children with exposure to prenatal MeHg from the Seychelles Child Development Study Nutrition Cohort 2.Neurotoxicology · 2023Article
- Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review.Toxics · 2023Article
- Article
- Reference Values on Children's Hair for 28 Elements (Heavy Metals and Essential Elements) Based on a Pilot Study in a Representative Non-Contaminated Local Area.International journal of molecular sciences · 2023Article
- Chronic Mercury Exposure andToxics · 2023Article
- A Role for Data Science in Precision Nutrition and Early Brain Development.Frontiers in psychiatry · 2022Review
- Environmentally relevant developmental methylmercury exposures alter neuronal differentiation in a human-induced pluripotent stem cell model.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021Article
- Associations of metals and neurodevelopment: a review of recent evidence on susceptibility factors.Current epidemiology reports · 2020Article
- Human-induced pluripotent stems cells as a model to dissect the selective neurotoxicity of methylmercury.Biochimica et biophysica acta. General subjects · 2019Review
- Post-translational modifications in MeHg-induced neurotoxicity.Biochimica et biophysica acta. Molecular basis of disease · 2019Review
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 4 countries.
Funding
Abstract
introductionGlutathione (GSH) pathways play a key role the metabolism and elimination of the neurotoxicant methylmercury (MeHg). We hypothesized that maternal genetic variation linked to GSH pathways could influence MeHg concentrations in pregnant mothers and children and thereby also affect early life development.
methodsThe GCLM (rs41303970, C/T), GCLC (rs761142, T/G) and GSTP1 (rs1695, A/G) polymorphisms were genotyped in 1449 mothers in a prospective study of the Seychellois population with a diet rich in fish. Genotypes were analyzed in association with maternal hair and blood Hg, fetal blood Hg (cord blood Hg), as well as children's mental (MDI) and motor development (PDI; MDI and PDI assessed by Bayley Scales of Infant Development at 20 months). We also examined whether genotypes modified the association between Hg exposure and developmental outcomes.
resultsGCLC rs761142 TT homozygotes showed statistically higher mean maternal hair Hg (4.12 ppm) than G carriers (AG 3.73 and GG 3.52 ppm) (p = 0.037). For the combination of GCLC rs761142 and GCLM rs41303970, double homozygotes TT + CC showed higher hair Hg (4.40 ppm) than G + T carriers (3.44 ppm; p = 0.018). No associations were observed between GSTP1 rs1695 and maternal hair Hg or between any genotypes and maternal blood Hg or cord blood Hg. The maternal GSTP1 rs1695 rare allele (G) was associated with a lower MDI among children (β = -1.48, p = 0.048). We also observed some interactions: increasing Hg in maternal and cord blood was associated with lower PDI among GCLC rs761142 TT carriers; and increasing Hg in hair was associated with lower MDI among GSTP1 rs1695 GG carriers.
conclusionsMaternal genetic variation in genes involved in GSH synthesis is statistically associated with Hg concentrations in maternal hair, but not in maternal or fetal blood. We observed interactions that suggest maternal GSH genetics may modify associations between MeHg exposure and neurodevelopmental outcomes.
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