Evidence map›Paper›PMID 29573442›Full record

ArticleAmerican journal of industrial medicine2018

Asbestos standards: Impact of currently uncounted chrysotile asbestos fibers on lifetime lung cancer risk.

David B Richardson, Alexander P Keil, Stephen R Cole, John Dement

Abstract read
In one paragraph

Article in American journal of industrial medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David B RichardsonDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-8550-0212
Alexander P KeilDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Stephen R ColeDepartment of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
John DementDivision of Occupational and Environmental Medicine, Duke University School of Medicine, Durham, North Carolina.

Funding

Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Occupational Exposure to Asbestos: Effects of Unregulated FibersR03OH010706 · OH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RICHARDSON, DAVID B · 2014 to 2015
$149k
NIEHS NIH HHS T32 ES007018NIOSH CDC HHS R03 OH010706
6 · The paper itself

Abstract

backgroundCurrent regulations require that asbestos fibers are collected and examined using a light microscope. This method fails to enumerate fibers that are too short or thin to reliably count using a light microscope under normal conditions.

methodsA cohort of 3054 workers employed at an asbestos textile plant was followed to ascertain causes of death. Exposure was almost entirely chrysotile. Fiber counts were quantified using light microscopy and electron microscopy. The g-formula was used to estimate impacts on lung cancer of policies defined in terms of fiber counts quantified using light and electron microscopy.

resultsGiven exposure at the current standard, the estimated lung cancer risk was 7.33%, comparable to the risk expected under a standard of 1 fiber/mL counted using electron microscopy (7.30%). The lifetime risk of lung cancer under a standard of 0.1 fiber/mL counted by electron microscopy was estimated to be 7.10%.

conclusionsWe identify policies defined in terms of electron microscopy-based asbestos exposure metrics that yield comparable, or lower, lung cancer mortality than that expected under the current standard.

Indexed as

AgedAged, 80 and overAsbestos, SerpentineCause of DeathCohort StudiesEnvironmental MonitoringFemaleHumansLung NeoplasmsMaleMicroscopy, ElectronMineral FibersMonte Carlo MethodOccupational DiseasesOccupational ExposureSouth CarolinaAsbestos, SerpentineMineral Fibersasbestoscohort studieslung cancermortality studyoccupational diseases

Identifiers

PMID29573442
PMCPMC5899641

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.