Evidence map›Paper›PMID 29573404›Full record

ArticleClinical and experimental immunology2018

Correlation of natural autoantibodies and cardiovascular disease-related anti-bacterial antibodies in pericardial fluid of cardiac surgery patients.

D Simon, O Gilicze, N Farkas, J Najbauer, P Németh, L Lénárd, T Berki

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Article in Clinical and experimental immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

D SimonDepartment of Immunology and Biotechnology, Clinical Center, Pécs, Hungary.
O GiliczeDepartment of Immunology and Biotechnology, Clinical Center, Pécs, Hungary.
N FarkasInstitute of Bioanalysis, University of Pécs Medical School, Pécs, Hungary.
J NajbauerDepartment of Immunology and Biotechnology, Clinical Center, Pécs, Hungary.ORCID 0000-0001-9856-9040
P NémethDepartment of Immunology and Biotechnology, Clinical Center, Pécs, Hungary.
L LénárdHeart Institute, University of Pécs Medical School, Pécs, Hungary.
T BerkiDepartment of Immunology and Biotechnology, Clinical Center, Pécs, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our previous studies showed that anti-citrate synthase (anti-CS) immunoglobulin (Ig)M natural autoantibodies are present in healthy individuals without previous antigen stimulation, but no studies have investigated their presence in the pericardial fluid (PF). Therefore, we detected the natural anti-CS IgG/M autoantibody levels in plasma and PF of cardiac surgery patients and investigated their relationship with cardiovascular disease-associated bacterial pathogens. PF and blood samples of 22 coronary artery bypass graft (CABG) and 10 aortic valve replacement (AVR) patients were tested for total Ig levels, natural autoantibodies and infection-related antibodies using enzyme-linked immunosorbent assay (ELISA) and Luminex methods. The B cell subsets were measured by flow cytometry. The total Ig subclass levels were four to eight times lower in PF than in plasma, but the natural anti-CS IgM autoantibodies showed a relative increase in PF. The frequency of CD19

Indexed as

Antibodies, BacterialAortic ValveAutoantibodiesB-Lymphocyte SubsetsBorrelia burgdorferiCardiovascular DiseasesChlamydophila pneumoniaeCitrate (si)-SynthaseCoronary Artery BypassEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedAntibodies, BacterialAutoantibodiesCitrate (si)-SynthaseImmunoglobulin GImmunoglobulin Manti-bacterial antibodiescardiovascular diseasecitrate synthasenatural autoantibodiespericardial fluid

Identifiers

PMID29573404
PMCPMC6037999
OpenAlexW2792987191

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.