Evidence map›Paper›PMID 29573356›Full record

ArticleMagnetic resonance in medicine2018

Optimization of selective inversion recovery magnetization transfer imaging for macromolecular content mapping in the human brain.

Richard D Dortch, Francesca Bagnato, Daniel F Gochberg, John C Gore, Seth A Smith

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Review
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  4. Magnetization transfer explains most of the TMagnetic resonance in medicine · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Richard D DortchDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Francesca BagnatoDepartment of Neurology/Neuroimmunology Division/Neuroimaging Unit, Vanderbilt University Medical Center, Nashville, Tennessee.
Daniel F GochbergDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
John C GoreDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Seth A SmithDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.

Funding

Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
Proton Relaxation and Exchange Contrast in MRIR01EB024525 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ZU, ZHONGLIANG · 2018 to 2021
$2.0M
Quantitative Assessment of Peripheral Nerve Injury and Repair via Multi-Parametric MRIR01NS097821 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DORTCH, RICHARD · 2016 to 2020
$1.7M
CERT Imaging of CancerR01CA184693 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2018
$1.6M
CERT Imaging of MuscleR01EB017767 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GOCHBERG, DANIEL F · 2014 to 2017
$1.4M
Microstructural Characterization of the Optic Nerve in Optic NeuritisR01EY023240 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SMITH, SETH A · 2014 to 2017
$1.0M
Quantitative MRI of the Human Peripheral Nervous System In VivoK25EB013659 · NIBIB · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DORTCH, RICHARD · 2012 to 2016
$750k
NCI NIH HHS R01 CA184693NEI NIH HHS R01 EY023240NIBIB NIH HHS K25 EB013659NIBIB NIH HHS R01 EB017767NIBIB NIH HHS R01 EB024525NICHD NIH HHS U54 HD083211NINDS NIH HHS R01 NS097821
6 · The paper itself

Abstract

purposeTo optimize a selective inversion recovery (SIR) sequence for macromolecular content mapping in the human brain at 3.0T. THEORY AND

methodsSIR is a quantitative method for measuring magnetization transfer (qMT) that uses a low-power, on-resonance inversion pulse. This results in a biexponential recovery of free water signal that can be sampled at various inversion/predelay times (t

resultsTwo optimal sampling schemes were determined: (i) a 5-point scheme (k

conclusionsqMT parameters can be robustly estimated in ≤1 min/slice (without independent measures of ΔB

Indexed as

AdultAlgorithmsBrainBrain ChemistryBrain MappingFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMyelin SheathPhantoms, Imagingcross-relaxationmyelinoptimizationquantitative magnetization transferselective inversion recovery

Identifiers

PMID29573356
PMCPMC6107392

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.