ReviewAging cell2018
The African turquoise killifish: A research organism to study vertebrate aging and diapause.
Review in Aging cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 171 citations in OpenAlex.
- Histo-anatomical atlas of Garra rufa and its thermal tolerance at human body temperature.Scientific reports · 2026Article
- Structural decomposition enables multi-omics dissection of common and organ-specific aging.Science China. Life sciences · 2026Article
- A lifespan atlas of the killifish testis defines a pronounced mid-age remodeling shift during testicular aging.BMC biology · 2026Article
- Engulfment by brain macrophages in a short-lived vertebrate.bioRxiv : the preprint server for biology · 2026Article
- Computational Approaches to Cancer Cell Dormancy: From Detection to Dynamic Modelling.Biomolecules · 2026Review
- A multi-omic atlas in the African turquoise killifish reveals increased glucocorticoid signaling as a hallmark of brain aging.bioRxiv : the preprint server for biology · 2026Article
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction.Kidney international · 2026Article
- Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish.Nature aging · 2026Article
- Spontaneous aging-associated inflammation and genome instability in the immune system of turquoise killifish.Nature aging · 2026Article
- Sexually Dimorphic Response to Dietary Restriction-induced Longevity and Muscle Rejuvenation inbioRxiv : the preprint server for biology · 2026Article
- First attempt at using a synthetic diet in short-lived killifish, a vertebrate model of ageing.Journal of fish biology · 2026Article
- Neither caloric nor protein restriction increases the male lifespan of outbred short-lived fish.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Spatial patterns of Wnt/β-catenin signaling in the adult and agingAging brain · 2026Article
- From Elixirs to Geroscience: A Historical and Molecular Perspective on Anti-Aging Medicine.Molecules (Basel, Switzerland) · 2025Review
- Ultrastructural Characteristics of the Juvenile Chum Salmon (International journal of molecular sciences · 2025Article
- An mTOR-Tfeb-Fabp7a Axis Ameliorates bag3 Cardiomyopathy via Decelerating Cardiac Aging.Aging cell · 2025Article
- Regeneration in fish, with special focus on killifishes.Fish physiology and biochemistry · 2025Review
- Enhanced C/EBPα Function Extends Healthspan and Lifespan in the African Turquoise Killifish.Aging cell · 2025Article
- Organization of Serotonergic Cell Populations in the Brain and Spinal Cord of the Short-Lived African Turquoise Killifish.Biology · 2025Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The African turquoise killifish has recently gained significant traction as a new research organism in the aging field. Our understanding of aging has strongly benefited from canonical research organisms-yeast, C. elegans, Drosophila, zebrafish, and mice. Many characteristics that are essential to understand aging-for example, the adaptive immune system or the hypothalamo-pituitary axis-are only present in vertebrates (zebrafish and mice). However, zebrafish and mice live more than 3 years and their relatively long lifespans are not compatible with high-throughput studies. Therefore, the turquoise killifish, a vertebrate with a naturally compressed lifespan of only 4-6 months, fills an essential gap to understand aging. With a recently developed genomic and genetic toolkit, the turquoise killifish not only provides practical advantages for lifespan and longitudinal experiments, but also allows more systematic characterizations of the interplay between genetics and environment during vertebrate aging. Interestingly, the turquoise killifish can also enter a long-term dormant state during development called diapause. Killifish embryos in diapause already have some organs and tissues, and they can last in this state for years, exhibiting exceptional resistance to stress and to damages due to the passage of time. Understanding the diapause state could give new insights into strategies to prevent the damage caused by aging and to better preserve organs, tissues, and cells. Thus, the African turquoise killifish brings two interesting aspects to the aging field-a compressed lifespan and a long-term resistant diapause state, both of which should spark new discoveries in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.