ArticleJournal of Korean medical science2018
Non-Motor Symptom Burdens Are Not Associated with Iron Accumulation in Early Parkinson's Disease: a Quantitative Susceptibility Mapping Study.
Article in Journal of Korean medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Putamen iron quantification in diseases with neurodegeneration: a meta-analysis of the quantitative susceptibility mapping technique.Brain imaging and behavior · 2024Pooled it
- Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases.Frontiers in neuroscience · 2021Pooled it
- Iron Imaging as a Diagnostic Tool for Parkinson's Disease: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- GABA outperforms iron and neuromelanin in detecting nigrostriatal alterations in early-stage Parkinson's disease with RBD.NPJ Parkinson's disease · 2025Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Evaluation of non-motor symptoms in Parkinson's disease using multiparametric MRI with the multiplex sequence.Frontiers in aging neuroscience · 2025Article
- Quantitative susceptibility mapping of subcortical iron deposition in Parkinson disease and multiple system atrophy: clinical correlations and diagnostic implications.Quantitative imaging in medicine and surgery · 2024Article
- Visualizing the deep cerebellar nuclei using quantitative susceptibility mapping: An application in healthy controls, Parkinson's disease patients and essential tremor patients.Human brain mapping · 2023Article
- Extra-basal ganglia iron content and non-motor symptoms in drug-naïve, early Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Sleep disturbances and gastrointestinal dysfunction are associated with thalamic atrophy in Parkinson's disease.BMC neuroscience · 2019Article
- The prevalence and unique clinical features of CPFE among patients with connective tissue disease-associated interstitial lung disease: a retrospective, real-world study.Therapeutic advances in respiratory diseaseArticle
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5 authors.
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Abstract
backgroundQuantitative susceptibility mapping (QSM) has been used to measure iron accumulation in the deep nuclei of patients with Parkinson's disease (PD). This study examined the relationship between non-motor symptoms (NMSs) and iron accumulation in the deep nuclei of patients with PD.
methodsThe QSM data were acquired from 3-Tesla magnetic resonance imaging (MRI) in 29 patients with early PD and 19 normal controls. The Korean version of the NMS scale (K-NMSS) was used for evaluation of NMSs in patients. The patients were divided into high NMS and low NMS groups. The region-of-interest analyses were performed in the following deep nuclei: red nucleus, substantia nigra pars compacta, substantia nigra pars reticulata, dentate nucleus, globus pallidus, putamen, and head of the caudate nucleus.
resultsThirteen patients had high NMS scores (total K-NMSS score, mean = 32.1), and 16 had low NMS scores (10.6). The QSM values in the deep were not different among the patients with high NMS scores, low NMS scores, and controls. The QSM values were not correlated linearly with K-NMSS total score after adjusting the age at acquisition of brain MRI.
conclusionThe study demonstrated that the NMS burdens are not associated with iron accumulation in the deep nuclei of patients with PD. These results suggest that future neuroimaging studies on the pathology of NMSs in PD should use more specific and detailed clinical tools and recruit PD patients with severe NMSs.
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