ArticlePediatric obesity2018
Associations of neonatal adiponectin and leptin with growth and body composition in African American infants.
Article in Pediatric obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Cord Blood Adipocytokines and Body Composition in Early Childhood: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles.International journal of molecular sciences · 2021Trial
- Associations Between Maternal and Cord Blood Leptin Levels and Anthropometry of Mothers and Infants.Nutrients · 2026Observational
- Unravelling the effect of parity on immunoglobulins, cytokines and adipokines in human transitional milk and their association with infant infections during the first 6 months of life.International breastfeeding journal · 2025Article
- Observational
- Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes.Pediatric obesity · 2023Article
- Breast milk immune composition varies during the transition stage of lactation: characterization of immunotypes in the MAMI cohort.Frontiers in nutrition · 2023Article
- Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice.International journal of molecular sciences · 2022Article
- Observational
- Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.European journal of nutrition · 2021Article
- Measuring growth and medium- and longer-term outcomes in malnourished children.Maternal & child nutrition · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCord blood adiponectin and leptin concentrations are associated with birth weight and adiposity. Birth size and rate of infant weight gain are associated with future obesity risk. However, it is unclear whether biomarkers reflecting the intrauterine environment are predictive of infant prospective body composition change.
objectivesTo examine whether cord blood adiponectin and leptin are predictive of neonatal adiposity and fat mass (FM) accrual to 3 months of age.
methodsParticipants (n = 36) were healthy African American infants. Leptin and adiponectin concentrations were measured in umbilical cord blood. At 2 weeks and 3 months, infant body composition was assessed via air displacement plethysmography. Weight-for-length z-scores (WLZ) were calculated using World Health Organization standards. Multiple linear regression was used to examine associations of cord blood adiponectin and leptin with birth WLZ; WLZ, FM and fat-free mass at 2 weeks, and the conditional change in these variables from 2 weeks to 3 months (body composition at 3 months adjusted for body composition at 2 weeks).
resultsAdiponectin was positively associated with FM at 2 weeks (r = 0.45, P < 0.01), but inversely associated with conditional FM change from 2 weeks to 3 months of age (r = -0.38, P < 0.05). Leptin was not significantly associated with infant body composition.
conclusionsAdiponectin may be a marker for FM accrual in African American infants, a relatively understudied population with a high long-term obesity risk. Mechanistic studies are needed to determine whether adiponectin directly influences infant growth or is simply a maker reflective of other ongoing biological changes after birth.
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