Evidence map›Paper›PMID 29573221›Full record

SynthesisJournal of diabetes investigation2018

Glycemic extremes are related to cognitive dysfunction in children with type 1 diabetes: A meta-analysis.

Jing He, Andrew G Ryder, Shichen Li, Wanting Liu, Xiongzhao Zhu

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of diabetes investigation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jing HeMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Andrew G RyderCenter for Clinical Research in Health & Department of Psychology, Concordia University, Montreal, Quebec, Canada.
Shichen LiMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Wanting LiuMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.
Xiongzhao ZhuMedical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China.ORCID http://orcid.org/0000-0002-0153-7163
Central South University · CNJewish General Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS/

introductionTo examine the magnitude and pattern of cognitive dysfunction in children with type 1 diabetes, and the possible effects associated with other disease variables, such as early onset diabetes, severe hypoglycemia and hyperglycemia. MATERIALS AND

methodsWe carried out a meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. We searched MedLine, Embase and PsycINFO to identify studies on cognitive function in children with type 1 diabetes that were published up until 30 September 2016. Effect sizes understood as the standardized mean differences between groups with diabetes and control groups (i.e., Hedges' g) were calculated to quantify the extent of cognitive dysfunction in those groups consisting of children with diabetes.

resultsA total of 19 studies met our inclusion criteria, comprising 1,355 participants with type 1 diabetes and 696 controls. Compared with non-diabetic controls, children with type 1 diabetes showed a significantly poorer cognitive performance overall (g = -0.46), as well as specific deficits in full-scale intelligence (g = -1.06), attention (g = -0.60) and psychomotor speed (g = -0.46). Glycemic extremes were associated with poorer overall cognition (g = -0.18), as well as slightly lower performance in memory (g = -0.27).

conclusionsWe found that type 1 diabetes was associated with cognitive dysfunction characterized by a lowered intelligence, diminished attention and a slowing of psychomotor speed. Glycemic extremes, which are described as a period of high glucose levels and severe hypoglycemia, were related to cognitive dysfunction in children with type 1 diabetes.

Indexed as

AdolescentBlood GlucoseChildChild, PreschoolCognitive DysfunctionDiabetes Mellitus, Type 1Glycated HemoglobinHumansHyperglycemiaHypoglycemiaBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanChildrenCognitive functionType 1 diabetes

Identifiers

PMID29573221
PMCPMC6215942
OpenAlexW2792620292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.