ArticleCytoskeleton (Hoboken, N.J.)2018
Spindle assembly in egg extracts of the Marsabit clawed frog, Xenopus borealis.
Article in Cytoskeleton (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Fixation and Expansion Microscopy ofBio-protocol · 2025Article
- Optimized expansion microscopy reveals species-specific spindle microtubule organization inMolecular biology of the cell · 2025Article
- Preparation of Xenopus borealis and Xenopus tropicalis Egg Extracts for Comparative Cell Biology and Evolutionary Studies.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Article
- Regulation of organelle size and organization during development.Seminars in cell & developmental biology · 2023Review
- Molecular conflicts disrupting centromere maintenance contribute to Xenopus hybrid inviability.Current biology : CB · 2022Article
- Affinity Purification of Label-free Tubulins fromSTAR protocols · 2020Article
- Organelle size scaling over embryonic development.Wiley interdisciplinary reviews. Developmental biology · 2020Review
- The power of amphibians to elucidate mechanisms of size control and scaling.Experimental cell research · 2020Review
- Kif2a Scales Meiotic Spindle Size in Hymenochirus boettgeri.Current biology : CB · 2019Article
- Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Egg extracts of the African clawed frog Xenopus laevis have provided a cell-free system instrumental in elucidating events of the cell cycle, including mechanisms of spindle assembly. Comparison with extracts from the diploid Western clawed frog, Xenopus tropicalis, which is smaller at the organism, cellular and subcellular levels, has enabled the identification of spindle size scaling factors. We set out to characterize the Marsabit clawed frog, Xenopus borealis, which is intermediate in size between the two species, but more recently diverged in evolution from X. laevis than X. tropicalis. X. borealis eggs were slightly smaller than those of X. laevis, and slightly smaller spindles were assembled in egg extracts. Interestingly, microtubule distribution across the length of the X. borealis spindles differed from both X. laevis and X. tropicalis. Extract mixing experiments revealed common scaling phenomena among Xenopus species, while characterization of spindle factors katanin, TPX2, and Ran indicate that X. borealis spindles possess both X. laevis and X. tropicalis features. Thus, X. borealis egg extract provides a third in vitro system to investigate interspecies scaling and spindle morphometric variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.