ArticleHuman brain mapping2018
Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The BrainHealth Project, a Longitudinal Study in Generally Healthy Adults
Breaking Through the Brain Fog: An Online RCT for Breast Cancer Survivors
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Coordinating Global Multi-Site Studies of Military-Relevant Traumatic Brain Injury: Opportunities, Challenges, and Harmonization Guidelines.Brain imaging and behavior · 2021Pooled it
- Measuring and increasing the brain health span across adulthood: a public health imperative.Scientific reports · 2026Trial
- Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury.Neural plasticity · 2021Trial
- The BrainHealth Project study protocol: a scalable digital approach to measuring and promoting multidimensional brain health across the lifespan.Frontiers in human neuroscience · 2025Article
- Validation of Strategic Memory Advanced Reasoning Training as an efficient and effective approach to treating warfighters with persistent cognitive complaints associated with mild traumatic brain injury.Frontiers in neurology · 2025Article
- Examining anterior prefrontal cortex resting-state functional connectivity patterns associated with depressive symptoms in chronic moderate-to-severe traumatic brain injury.Frontiers in neurology · 2025Article
- Effectiveness of Cognitive Rehabilitation in Improving Symptoms and Restoring Cognitive Functions in Patients with Depression: An Updated Meta-Analysis of Randomized Controlled Trials.Alpha psychiatry · 2024Review
- Exploring how brain health strategy training informs the future of work.Frontiers in psychology · 2023Article
- Transcranial direct current stimulation modulates working memory and prefrontal-insula connectivity after mild-moderate traumatic brain injury.Frontiers in human neuroscience · 2022Article
- Efficacy of Cognitive Training When Translated From the Laboratory to the Real World.Military medicine · 2021Article
- A Novel BrainHealth Index Prototype Improved by Telehealth-Delivered Training During COVID-19.Frontiers in public health · 2021Article
- Testing the Mechanism of Action of Computerized Cognitive Training in Young Adults with Depression: Protocol for a Blinded, Randomized, Controlled Treatment Trial.Journal of psychiatry and brain science · 2020Article
- Cerebral Perfusion Effects of Cognitive Training and Transcranial Direct Current Stimulation in Mild-Moderate TBI.Frontiers in neurology · 2020Article
- Neuroimaging and Neuropsychological Outcomes Following Clinician-Delivered Cognitive Training for Six Patients With Mild Brain Injury: A Multiple Case Study.Frontiers in human neuroscience · 2020Article
- Neural correlates of reduced depressive symptoms following cognitive training for chronic traumatic brain injury.Human brain mapping · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is the most frequent comorbid psychiatric condition among individuals with traumatic brain injury (TBI). Yet, little is known about changes in the brain associated with reduced depressive symptoms following rehabilitation for TBI. We identified whether cognitive training alleviates comorbid depressive symptoms in chronic TBI (>6 months post-injury) as a secondary effect. Further, we elucidated neural correlates of alleviated depressive symptoms following cognitive training. A total of seventy-nine individuals with chronic TBI (53 depressed and 26 non-depressed individuals, measured using the Beck Depressive Inventory [BDI]), underwent either strategy- or information-based cognitive training in a small group for 8 weeks. We measured psychological functioning scores, cortical thickness, and resting-state functional connectivity (rsFC) for these individuals before training, immediately post-training, and 3 months post-training. After confirming that changes in BDI scores were independent of training group affiliation, we identified that the depressive-symptoms group showed reductions in BDI scores over time relative to the non-depressed TBI controls (p < .01). Within the depressive-symptoms group, reduced BDI scores was associated with improvements in scores for post-traumatic stress disorder, TBI symptom awareness, and functional status (p < .00625), increases in cortical thickness in four regions within the right prefrontal cortex (p
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.