ArticleAnnals of neurology2018
Developmental conduction aphasia after neonatal stroke.
Article in Annals of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- School-age outcomes of children after perinatal brain injury: a systematic review and meta-analysis.BMJ paediatrics open · 2023Pooled it
- Oral language profiles and associated factors in children after neonatal arterial ischaemic stroke.Developmental medicine and child neurology · 2026Article
- Distinct thalamic functional connectivity and volume patterns across focal epilepsies in children: A multimodal neuroimaging study.Epilepsia · 2026Article
- Long-Term Cognitive and Language Outcomes at the Age of Seven Following Arterial Presumed Perinatal Ischemic Stroke: A Case Report.Brain sciences · 2025Article
- White matter microstructure in language tracts in youth with perinatal stroke.Brain imaging and behavior · 2025Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- Risk Factors for Perioperative Brain Lesions in Infants With Congenital Heart Disease: A European Collaboration.Stroke · 2022Article
- Lesion Distribution and Early Changes of Right Hemisphere in Chinese Patients With Post-stroke Aphasia.Frontiers in aging neuroscience · 2021Article
- Language development and brain reorganization in a child born without the left hemisphere.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Pharmacotherapy of Traumatic Childhood Aphasia: Beneficial Effects of Donepezil Alone and Combined With Intensive Naming Therapy.Frontiers in pharmacology · 2020Article
- Developmental Dynamic Dysphasia: Are Bilateral Brain Abnormalities a Signature of Inefficient Neural Plasticity?Frontiers in human neuroscience · 2020Article
- Corticobulbar Tract Injury, Oromotor Impairment and Language Plasticity in Adolescents Born Preterm.Frontiers in human neuroscience · 2019Article
- Functional connectivity of language networks after perinatal stroke.NeuroImage. Clinical · 2019Article
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6 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveImpairment of speech repetition following injury to the dorsal language stream is a feature of conduction aphasia, a well-described "disconnection syndrome" in adults. The impact of similar lesions sustained in infancy has not been established.
methodsWe compared language outcomes in term-born individuals with confirmed neonatal stroke (n = 30, age = 7-18 years, left-sided lesions in 21 cases) to matched controls (n = 40). Injury to the dorsal and/or ventral language streams was assessed using T
resultsAt the group level, left dorsal language stream injury was associated with selective speech repetition impairment for nonwords (p = 0.021) and sentences (p < 0.0001). The majority of children with significant repetition impairment had retained left hemisphere language representation, but right hemisphere dominance was correlated with minimal or absent repetition deficits. Post hoc analysis of the repetition-impaired group revealed additional language-associated deficits, but these were more subtle and variable.
interpretationWe conclude that (1) despite the considerable plasticity of the infant brain, early dorsal language stream injury can result in specific and long-lasting problems with speech repetition that are similar to the syndrome of conduction aphasia seen in adults; and (2) language reorganization to the contralateral hemisphere has a protective effect. Ann Neurol 2018;83:664-675 Ann Neurol 2018;83:664-675.
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