Evidence map›Paper›PMID 29572702›Full record

ArticleCancer immunology, immunotherapy : CII2018

Depleted polymorphonuclear leukocytes in human metastatic liver reflect an altered immune microenvironment associated with recurrent metastasis.

Fiona Hand, Cathal Harmon, Louise A Elliott, Francesco Caiazza, Aonghus Lavelle, Donal Maguire, Emir Hoti, Niamh Nolan, Justin G Geoghegan, Elizabeth J Ryan and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer immunology, immunotherapy : CII, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Liver-Derived TGF-β Maintains the EomesFrontiers in immunology · 2019
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Fiona HandNational Liver Unit, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Cathal HarmonSchool of Biochemistry and Immunology and School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 154-160 Pearse Street, Dublin 2, D02 R590, Ireland.
Louise A ElliottCentre for Colorectal Disease, School of Medicine, University College Dublin and St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Francesco CaiazzaCentre for Colorectal Disease, School of Medicine, University College Dublin and St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Aonghus LavelleCentre for Colorectal Disease, School of Medicine, University College Dublin and St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Donal MaguireNational Liver Unit, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Emir HotiNational Liver Unit, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Niamh NolanNational Liver Unit, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Justin G GeogheganNational Liver Unit, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Elizabeth J RyanCentre for Colorectal Disease, School of Medicine, University College Dublin and St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.
Cliona O'FarrellySchool of Biochemistry and Immunology and School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, 154-160 Pearse Street, Dublin 2, D02 R590, Ireland. OFARRECL@tcd.ie.ORCID http://orcid.org/0000-0002-0616-2874
St. Vincent's University Hospital · IEUniversity College Dublin · IETrinity College Dublin · IE

Funding

Health Research Board HRA-POR-2013-281Health Research Board RP 2008/189Science Foundation Ireland 132/IA/1667
6 · The paper itself

Abstract

backgroundHepatic immunity, normally protective against neoplasia, is subverted in colorectal liver metastasis (CRLM). Here, we compare the inflammatory microenvironment of CRLM-bearing liver tissue to donor liver.

methodsTwenty-five patients undergoing resection for CRLM were recruited, 13 of whom developed intrahepatic recurrence within 18 months. Biopsies were obtained from tumour and normal liver tissue adjacent to and distal from, the tumour. Donor liver biopsies were obtained during transplantation. Biopsies were cultured and conditioned media (CM) screened for 102 inflammatory mediators. Twelve of these were validated by Luminex assay. Transwell assays measured cancer cell chemotaxis. Polymorphonuclear leukocytes (PMN) and lymphocytes were quantified in H&E sections.

resultsFewer periportal tissue-resident PMN were present in metastatic liver compared to donor liver. Patients with the fewest PMN in liver tissue distal to their tumour had a shorter time to intrahepatic recurrence (P < 0.001). IL-6, CXCL1, CXCL5, G-CSF, GM-CSF, VEGF, LIF, and CCL3 were higher in liver-bearing CRLM compared to donor tissue. Consequently, cancer cells migrated equally towards CM of all regions of metastatic liver but not towards donor liver CM.

conclusionsThe local inflammatory environment may affect both immune cell infiltration and cancer cell migration contributing to recurrence following resection for CRLM.

Indexed as

AdultAgedAged, 80 and overCase-Control StudiesColorectal NeoplasmsFemaleFollow-Up StudiesHumansInflammation MediatorsLeukocytesLiver NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm Recurrence, LocalNeutrophilsInflammation MediatorsColorectal liver metastasesImmune microenvironmentLeukocytesTumour progression

Identifiers

PMID29572702
PMCPMC11028161
OpenAlexW2790130787

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.