Trial reportJournal of assisted reproduction and genetics2018
The effect of swim-up and gradient sperm preparation techniques on deoxyribonucleic acid (DNA) fragmentation in subfertile patients.
Trial report in Journal of assisted reproduction and genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Effect of ejaculatory abstinence period on sperm DNA fragmentation and pregnancy outcome of intrauterine insemination cycles: A prospective randomized study.Archives of gynecology and obstetrics · 2021Trial
- Trial
- Sequencing Matters: Comparative Effectiveness of Density-Gradient Centrifugation and MACS for Enhancing Sperm Quality and DNA Integrity.Journal of clinical medicine · 2026Article
- Normozoospermic infertile men possess subpopulations of sperm varying in DNA accessibility, relating to differing reproductive outcomes.Human reproduction (Oxford, England) · 2025Article
- Sperm oxidative damage acquired during seminal plasma removal for assisted reproductive technology is reduced by BGP-15.Journal of assisted reproduction and genetics · 2025Article
- Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes.FASEB bioAdvances · 2024Review
- Sperm Migration and Hyaluronic Acid Binding: Implications for Male Fertility Evaluation.International journal of molecular sciences · 2024Article
- Timing of semen cryopreservation: before or after processing?Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024Article
- Comparison between density gradient centrifugation method, an extended version of the horizontal swim up method and the combination of both for sperm selection.Obstetrics & gynecology science · 2023Article
- A comprehensive evaluation of pre- and post-processing sperm parameters for predicting successful pregnancy rate following intrauterine insemination with the husband's sperms.BMC pregnancy and childbirth · 2022Article
- Does Microfluidic Sperm Sorting Affect Embryo Euploidy Rates in Couples with High Sperm DNA Fragmentation?Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Magnetic-Activated Cell Sorting as a Method to Improve Necrozoospermia-Related Asthenozoospermic Samples.Journal of clinical medicine · 2022Article
- Effects of sperm preparation techniques on sperm survivability and DNA fragmentation.The Journal of international medical research · 2022Article
- Cumulative live birth rates after IVF/ICSI cycles with sperm prepared by density gradient centrifugation vs. swim-up: a retrospective study using a propensity score-matching analysis.Reproductive biology and endocrinology : RB&E · 2022Article
- Correlations between elevated basal sperm DNA fragmentation and the clinical outcomes in women undergoing IUI.Frontiers in endocrinology · 2022Article
- An Update on Semen Physiology, Technologies, and Selection Techniques for the Advancement of In Vitro Equine Embryo Production: Section II.Animals : an open access journal from MDPI · 2021Review
- Mitochondria Content and Activity Are Crucial Parameters for Bull Sperm Quality Evaluation.Antioxidants (Basel, Switzerland) · 2021Article
- Sperm selection during ICSI treatments reduces single- but not double-strand DNA break values compared to the semen sample.Journal of assisted reproduction and genetics · 2021Article
- A Simple, Centrifugation-Free, Sperm-Sorting Device Eliminates the Risks of Centrifugation in the Swim-Up Method While Maintaining Functional Competence and DNA Integrity of Selected Spermatozoa.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Sperm DNA Fragmentation: A New Guideline for Clinicians.The world journal of men's health · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the effect of two different sperm preparation techniques, including swim-up and gradient methods on sperm deoxyribonucleic acid (DNA) fragmentation status of semen samples from unexplained and mild male factor subfertile patients undergoing intrauterine insemination (IUI).
designA prospective randomized study was conducted in 65 subfertile patients, including 34 unexplained and 31 male factor infertility to compare basal and post-procedure DNA fragmentation rates in swim-up and gradient techniques. Sperm DNA fragmentation rates were evaluated by a sperm chromatin dispersion (SCD) test in two portions of each sample of semen that was prepared with either swim-up or gradient techniques. Sperm motility and morphology were also assessed based on WHO 2010 criteria.
resultsSwim-up but not gradient method yielded a statistically significant reduction in the DNA fragmented sperm rate after preparation as compared to basal rates, in the semen samples of both unexplained (41.85 ± 22.04 vs. 28.58 ± 21.93, p < 0.001 for swim-up; and 41.85 ± 22.04 vs. 38.79 ± 22.30, p = 0.160 for gradient) and mild male factor (46.61 ± 19.38 vs. 30.32 ± 18.20, p < 0.001 for swim-up and 46.61 ± 19.38 vs. 44.03 ± 20.87, p = 0.470 for gradient) subgroups.
conclusionsSwim-up method significantly reduces sperm DNA fragmentation rates and may have some prognostic value on intrauterine insemination in patients with decreased sperm DNA integrity.
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Registered trials
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