ArticleClinical oral investigations2019
Periodontal and endodontic infectious/inflammatory profile in primary periodontal lesions with secondary endodontic involvement after a calcium hydroxide-based intracanal medication.
Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Prevalence of species of yellow, purple and green microbial complexes in endo-perio lesions: a systematic review.Brazilian oral research · 2024Pooled it
- Influence of intracanal medicaments on the periodontal and periapical healing in concurrent endodontic-periodontal lesions with/without communication: a systematic review and meta-analysis.Clinical oral investigations · 2023Pooled it
- Prevalence of red and orange microbial complexes in endodontic-periodontal lesions: a systematic review and meta-analysis.Clinical oral investigations · 2021Pooled it
- Postoperative pain in endodontic retreatment of one visit versus multiple visits: a systematic review and meta-analysis of randomized controlled trials.Clinical oral investigations · 2021Pooled it
- Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis.Clinical oral investigations · 2019Trial
- The conundrum of current endodontic disinfection strategies in microbial load reduction: a scoping review.BMC oral health · 2026Article
- Interpreting Endodontic-Periodontal Lesions: A Conceptual Framework Based on Pulpal and Periodontal Findings-A Narrative Review.Dentistry journal · 2026Review
- Management of the endodontic-periodontal lesion.British dental journal · 2025Review
- Challenges in Optimizing Nanoplatforms Used for Local and Systemic Delivery in the Oral Cavity.Pharmaceutics · 2024Review
- Temporary Root Canal Obturation with a Calcium Hydroxide-Based Dressing: A Randomized Controlled Clinical Trial.Antibiotics (Basel, Switzerland) · 2023Article
- Therapeutic Potential of Chlorhexidine-Loaded Calcium Hydroxide-Based Intracanal Medications in Endo-Periodontal Lesions: An Ex Vivo and In Vitro Study.Antibiotics (Basel, Switzerland) · 2023Article
- Clinical influence of calcium hydroxide intracanal medications on matrix metalloproteinases and tissue inhibitors of metalloproteinases in apical periodontitis.Clinical oral investigations · 2022Article
- Comparative analysis of bacterial content, levels of lipopolysaccharides and lipoteichoic acid in symptomatic and asymptomatic endodontic infections at different stages of endodontic treatment.Clinical oral investigations · 2022Article
- Osteoclast formation, inflammation, and matrix metalloproteinase-9 are downregulated in bone repair following root canal treatment in dogs teeth.Clinical oral investigations · 2021Article
- Patterns of Oral Microbiota in Patients with Apical Periodontitis.Journal of clinical medicine · 2021Article
- Microbiological analysis of endodontically treated teeth with apical periodontitis before and after endodontic retreatment.Clinical oral investigations · 2021Article
- Microbiological Investigation in Teeth with Persistent/Secondary Endodontic Infection in Different Stages of Root Canal Retreatment.European endodontic journal · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe aim of the present study was to investigate the effects of a calcium hydroxide-based intracanal medication (ICM) on periodontal and endodontic infectious/inflammatory contents and on periodontal clinical parameters in teeth with primary periodontal lesion and secondary endodontic involvement. MATERIALS AND
methodsTen patients with abnormal pulp test results and deep probing depth derived from primary periodontal disease with secondary endodontic involvement were included. Samples were collected from root canals (RC) and periodontal pockets (PP) in order to investigate the microbiological status, levels of endotoxin (LPS), cytokines, and matrix metalloproteinases (MMP), before and after ICM. PCR was used for microbiological assessment. The kinetic-chromogenic LAL assay was used for LPS quantification. Quantikine ELISA kits were used for measurement of IL-1 α, IL-1 β, TNF-α, PGE
resultsICM did not reduce the number of microorganisms in PP and RC, except for Fusobacterium nucleatum in RC. There was a significant reduction in LPS, MMPs, IL-1 β, and TNF-α levels in PP after ICM. In RC, LPS, MMP13, PGE
conclusionsThe use of a calcium hydroxide-based ICM showed positive effects for periodontal treatment prognosis, as it reduced LPS, cytokine, and MMP levels in periodontal pockets. CLINICAL SIGNIFICANCE: Patients presenting deep probing depth and undergoing periodontal treatment for at least 6 months, with no positive response to periodontal therapy, might benefit with the endodontic treatment.
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