Evidence map›Paper›PMID 29572675›Full record

ArticleClinical neuroradiology2019

Cerebral Perforating Artery Disease : Characteristics on High-Resolution Magnetic Resonance Imaging.

Jianye Liang, Yiyong Liu, Xiaoshuang Xu, Changzheng Shi, Liangping Luo

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Clinical neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06037889 (Efficacy and Safety of Tirofiban in Patients With Acute Branch Atheromatous Disease), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06037889 phase3completednot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of Tirofiban in Patients With Acute Branch Atheromatous Disease (BAD)- Related Stroke (BRANT)

TypeinterventionalSponsorPeking Union Medical College HospitalRan2023 to 2026Enrolled516ConditionsBranch Atheromatous DiseaseArmsTirofiban, Aspirin tablet, Clopidogrel tablet
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Short-TR Acquisition Time-of-flight MR Angiography with Deep Learning Reconstruction: Technical Feasibility and Initial Clinical Evaluation in Moyamoya Disease.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
    Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jianye LiangMedical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Yiyong LiuMedical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Xiaoshuang XuMedical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.
Changzheng ShiMedical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China. tsczcn@jnu.edu.cn.
Liangping LuoMedical Imaging Center, The First Affiliated Hospital, Jinan University, Guangzhou, China. tluolp@jnu.edu.cn.
First Affiliated Hospital of Jinan University · CN

Funding

Collaborative Innovation Program of Hong Kong and Guangdong Province 2016A050503032
6 · The paper itself

Abstract

purposeOur aims were to evaluate the feasibility of high-resolution magnetic resonance imaging (HR-MRI) for displaying the cerebral perforating arteries in normal subjects and to discuss the value of HR-MRI for detecting the causes of infarctions in the territory of the lenticulostriate artery (LSA).

methodsIncluded in this study were 31 healthy subjects and 28 patients who had infarctions in the territory supplied by the LSA. The T1-weighted imaging (T1WI), T2WI, diffusion-weighted imaging (DWI), and HR-MRI, including 3‑dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA) and 3D fast spin-echo T1WI (namely CUBE T1 in GE Healthcare), were applied on a 3-Tesla scanner. The numbers and route of the perforating arteries on both sides were independently confirmed on HR-MRI by two physicians. The Wilcoxon test was used to compare the differences.

resultsThe numbers of perforating arteries in healthy subjects observed on 3D-TOF-MRA were as follows: numbers of the bilateral recurrent artery of Heubner (RAH) ranged from 0-3 (median 1), numbers of the left LSA ranged from 0-7 (median 3), numbers of the right LSA ranged from 0-5 (median 3), numbers of the bilateral anterior choroidal artery ranged from 1-2 (median 1) and the numbers of the bilateral thalamoperforating artery ranged from 1-2 (median 1). In the patients with lenticulostriate infarctions, the numbers of LSAs on the affected side were lower than on the opposite and ipsilateral sides in the healthy subjects. The results were statistically significant. An abnormality of the RAH may lead to a centrum semiovale infarct pattern, whereas an abnormality of the LSA is associated with a corona radiata infarct pattern.

conclusionThe use of HR 3D-TOF-MRA and CUBE T1 had unique advantages in displaying the tiny perforating arteries in vivo. Moreover, effective recognition of the associated cerebral perforating artery and infarct patterns may enhance our understanding of the mechanism of stroke in patients with lenticulostriate infarctions.

Indexed as

AdolescentAdultAgedBasal Ganglia Cerebrovascular DiseaseCerebral ArteriesCerebral InfarctionChildFeasibility StudiesFemaleHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesStatistics, NonparametricFast spin-echoInfarct patternLenticulostriate infarctionMagnetic resonance angiographyStroke mechanism

Identifiers

PMID29572675
OpenAlexW2790954559

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.