Evidence map›Paper›PMID 29572578›Full record

ArticleJapanese journal of ophthalmology2018

Crucial role of P2X

Atsunobu Takeda, Hisakata Yamada, Eiichi Hasegawa, Mitsuru Arima, Shoji Notomi, Sayaka Myojin, Takeru Yoshimura, Toshio Hisatomi, Hiroshi Enaida, Ryoji Yanai and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Japanese journal of ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  8. Calcium signalling in T cells.Nature reviews. Immunology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Atsunobu TakedaDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. atakeda@med.kyushu-u.ac.jp.
Hisakata YamadaDivision of Host Defense, Research Center for Prevention of Infectious Diseases, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Eiichi HasegawaDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Mitsuru ArimaDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Shoji NotomiDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Sayaka MyojinDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Takeru YoshimuraDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Toshio HisatomiDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Hiroshi EnaidaDepartment of Ophthalmology, Faculty of Medicine, Saga University, Saga, Saga, Japan.
Ryoji YanaiDepartment of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan.
Kazuhiro KimuraDepartment of Ophthalmology, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi, Japan.
Tatsuro IshibashiDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Kyushu University · JPYamaguchi University · JPSaga University · JP

Funding

KAKENHI, the Ministry of Education, Science, Sports and Culture, Japan 10294943KAKENHI, the Ministry of Education, Science, Sports and Culture, Japan 15K10896
6 · The paper itself

Abstract

purposeTo investigate the roles of P2X7 receptors (P2RX7) in the pathogenesis of experimental autoimmune uveoretinitis (EAU). STUDY

designExperimental.

methodsEither wild-type (P2rx7

resultsThe severity of EAU in P2rx7

conclusionThe results suggest that P2RX7 is a novel preventative therapeutic target for uveitis as it suppresses the effector functions of both Th1 and Th17 cell responses.

Indexed as

AnimalsAutoimmune DiseasesDisease Models, AnimalEnzyme-Linked Immunosorbent AssayFemaleLymphocyte ActivationMiceMice, Inbred C57BLReceptors, Purinergic P2X7T-LymphocytesUveitisReceptors, Purinergic P2X7BBGCD4+ T cellsEAUP2RX7Uveitis

Identifiers

PMID29572578
OpenAlexW2791870163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.