Evidence map›Paper›PMID 29572571›Full record

ArticleJournal of neurology2018

Exploring the relationship between motor impairment, vascular burden and cognition in Parkinson's disease.

Tanja Stojkovic, Elka Stefanova, Ivan Soldatovic, Vladana Markovic, Iva Stankovic, Igor Petrovic, Federica Agosta, Sebastiano Galantucci, Massimo Filippi, Vladimir Kostic

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  17. Evolving concepts on bradykinesia.Brain : a journal of neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Tanja StojkovicNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia. tanjili80@gmail.com.ORCID http://orcid.org/0000-0001-7113-7520
Elka StefanovaNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Ivan SoldatovicInstitute of Medical Statistics, Belgrade, Serbia.
Vladana MarkovicNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Iva StankovicNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Igor PetrovicNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
Federica AgostaNeuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Sebastiano GalantucciNeuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Massimo FilippiNeuroimaging Research Unit, Division of Neuroscience, Institute of Experimental Neurology, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
Vladimir KosticNeurology Clinic, Clinical Center of Serbia, Belgrade, Serbia.
University of Belgrade · RSVita-Salute San Raffaele University · ITCentar za Promociju Nauke · RS

Funding

This study was partially funded by a grant from the Ministry of Education and Science, Republic of Serbia 175090
6 · The paper itself

Abstract

objectiveTo determine frequency and type of cognitive disorders in cross-sectional analysis of a Parkinson's disease (PD) cohort, and explore its relations to motor symptoms, modifiable vascular risk factors and white matter lesions (WML) volume.

methodsIn a group of 133 PD patients, mild cognitive impairment (PD-MCI) and dementia (PDD) were diagnosed according to Movement Disorders Society Task Force criteria (level 2 for PD-MCI). Detailed motor measurements were applied, including rigidity, axial, bradykinesia, tremor and postural instability gait disorders (PIGD) scores. Vascular risk was estimated by the Framingham General Cardiovascular Disease risk scoring algorithm and WML volume was measured for whole brain and frontal lobe.

resultsSixty-one (46.9%) patients fulfilled criteria for PD-MCI, and 23 (17.7%) for PDD. Non-amnestic multiple domain MCI was most frequent (52% of PD-MCI patients). Motor scores were significantly higher in cognitively impaired patients, but only axial score discriminated between MCI and dementia. High vascular risk was related to impaired cognition, bradykinesia, axial, PIGD and freezing of gait (FOG) score, while whole brain WML volume was associated with PDD, FOG and attention deficits. Furthermore, high vascular risk was identified as a potential predictor of both MCI and dementia in PD. Additionally, age and bradykinesia score were independently associated with PD-MCI and age, axial score and whole brain WML volume with PDD.

conclusionCognitive disorders in PD are associated with more severe, predominantly axial motor deficits and increased, but partly modifiable vascular burden, thus opening a possibility for development of preventive strategies in PD.

Indexed as

AgedBrainCardiovascular DiseasesCognitionCognitive DysfunctionCohort StudiesCross-Sectional StudiesDementiaFemaleHumansMaleMiddle AgedMovement DisordersOrgan SizeParkinson DiseaseRisk FactorsCognitionGaitParkinson’s diseaseVascular risk

Identifiers

PMID29572571
OpenAlexW2794239424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.