ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2018
Basophil-lineage commitment in acute promyelocytic leukemia predicts for severe bleeding after starting therapy.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Acute Promyelocytic Leukemia With a Subgroup Exhibiting Basophilic Differentiation.International journal of laboratory hematology · 2026Article
- Basophils in Acute Promyelocytic Leukemia: Clonality or Reactiveness?Turkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Review
- Three-Way Translocation t(12;15;17) (p13;q24;q21) Found in Acute Promyelocytic Leukemia with Basophilic Differentiation.Hematology reports · 2024Article
- Acute Promyelocytic Leukemia with Basophilic Differentiation: A Rare VariantTurkish journal of haematology : official journal of Turkish Society of Haematology · 2024Article
- Acute promyelocytic leukemia presenting with atypical basophils.Clinical case reports · 2020Article
- A novel flow cytometric method for enhancing acute promyelocytic leukemia screening by multidimensional dot-plots.Annals of hematology · 2019Article
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Authors and funding
28 authors at 14 institutions in 2 countries.
Funding
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Abstract
Severe hemorrhagic events occur in a significant fraction of acute promyelocytic leukemia patients, either at presentation and/or early after starting therapy, leading to treatment failure and early deaths. However, identification of independent predictors for high-risk of severe bleeding at diagnosis, remains a challenge. Here, we investigated the immunophenotype of bone marrow leukemic cells from 109 newly diagnosed acute promyelocytic leukemia patients, particularly focusing on the identification of basophil-related features, and their potential association with severe bleeding episodes and patient overall survival.From all phenotypes investigated on leukemic cells, expression of the CD203c and/or CD22 basophil-associated markers showed the strongest association with the occurrence and severity of bleeding (p ≤ 0.007); moreover, aberrant expression of CD7, coexpression of CD34
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