ArticleNature communications2018
A neuronal basis for fear discrimination in the lateral amygdala.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Complementary stable and dynamic prelimbic ensembles encode learned threat value underlying generalization and discrimination.bioRxiv : the preprint server for biology · 2026Article
- Neural mechanisms of fear memory precision and generalization: from auditory cortex to amygdala.Translational psychiatry · 2026Review
- Chronic stress enhances threat responding and impacts fear extinction.Learning & memory (Cold Spring Harbor, N.Y.) · 2026Article
- Sex-Specific Associations of Irritability With Subcortical Brain Volumes.Biological psychiatry global open science · 2026Article
- Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts.World journal of psychiatry · 2026Article
- Psychometric Considerations in Assessing Fear Generalization as a Predictor of Anxiety.Biological psychiatry global open science · 2025Article
- Endocannabinoids inhibit contextual fear memory generalization via hippocampal GABAergic synaptic transmission.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Polyunsaturated fatty-acids diet increases fear discrimination in rats and IGF-2 receptors signaling in the auditory cortex.Scientific reports · 2025Article
- Prefrontal correlates of fear generalization during endocannabinoid depletion.The Journal of clinical investigation · 2025Article
- Auditory fear memory retrieval requires BLA-LS and LS-VMH circuitries via GABAergic and dopaminergic neurons.EMBO reports · 2025Article
- The roles of amygdala subnuclei in processing of approaching in- and outgroup others in virtual space.Social cognitive and affective neuroscience · 2025Article
- Fear generalization modulated by shock intensity and protein synthesis inhibitor.Psychopharmacology · 2024Article
- Overgeneralization of autonomic defensive reactions in obesity.Scientific reports · 2024Article
- Article
- PREFRONTAL CORRELATES OF FEAR GENERALIZATION DURING ENDOCANNABINOID DEPLETION.bioRxiv : the preprint server for biology · 2024Article
- Stabilizing Immature Dendritic Spines in the Auditory Cortex: A Key Mechanism for mTORC1-Mediated Enhancement of Long-Term Fear Memories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning.Nature communications · 2023Article
- Quantification of prefrontal cortical neuronal ensembles following conditioned fear learning in a Fos-LacZ transgenic rat with photoacoustic imagingPhotoacoustics · 2023Article
- Specific behaviors during auditory fear conditioning and postsynaptic expression of AMPA receptors in the basolateral amygdala predict interindividual differences in fear generalization in male rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2023Article
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Authors and funding
5 authors.
Funding
Abstract
In the presence of new stimuli, it is crucial for survival to react with defensive responses in the presence of stimuli that resemble threats but also to not react with defensive behavior in response to new harmless stimuli. Here, we show that in the presence of new uncertain stimuli with sensory features that produce an ambiguous interpretation, discriminative processes engage a subset of excitatory and inhibitory neurons within the lateral amygdala (LA) that are partially different from those engaged by fear processes. Inducing the pharmacogenetic deletion of this neuronal ensemble caused fear generalization but left anxiety-like response, fear memory and extinction processes intact. These data reveal that two opposite neuronal processes account for fear discrimination and generalization within the LA and suggest a potential pathophysiological mechanism for the impaired discrimination that characterizes fear-related disorders.
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