ArticleBlood2018
Preclinical evaluation of
Open access · bronzeAbstract read
In one paragraph
Article in Blood, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
6.7field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Association ofHaematologica · 2024Pooled it
- DNA-thioguanine nucleotide as a treatment marker in acute lymphoblastic leukemia patients with NUDT15 variant genotypes.PloS one · 2021Trial
- Personalized Therapy with Mercaptopurine in Acute Lymphoblastic Leukemia: Current Advances and Challenges.Current treatment options in oncology · 2026Review
- Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium.Pediatric blood & cancer · 2026Article
- Article
- Review
- The NUDIX hydrolase NUDT5 regulates thiopurine metabolism and cytotoxicity.The Journal of clinical investigation · 2025Article
- Azathioprine Metabolites in Erythrocytes and DNA for Therapy Monitoring in Very Early Onset Inflammatory Bowel Disease Pediatric Patients.ACS pharmacology & translational science · 2025Article
- The evaluation of the impact of NUDT15 variants on thiopurine metabolism in Japanese children with acute lymphoblastic leukemia.Cancer chemotherapy and pharmacology · 2025Article
- Clinical Actionability of the NUDT15 *4 (p.R139H) Allele and Its Association With Hispanic Ethnicity.Clinical pharmacology and therapeutics · 2025Article
- Nudt15-mediated inflammatory signaling contributes to divergent outcomes in leukemogenesis and hematopoiesis.Leukemia · 2024Article
- Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations.Journal of the National Cancer Institute · 2024Article
- Pro-905, a Novel Purine Antimetabolite, Combines with Glutamine Amidotransferase Inhibition to Suppress Growth of Malignant Peripheral Nerve Sheath Tumor.Molecular cancer therapeutics · 2023Article
- Mammalian Nudt15 hydrolytic and binding activity on methylated guanosine mononucleotides.European biophysics journal : EBJ · 2023Article
- Targeting pan-essential pathways in cancer with cytotoxic chemotherapy: challenges and opportunities.Cancer chemotherapy and pharmacology · 2023Review
- Long-read HiFi sequencing of NUDT15: Phased full-gene haplotyping and pharmacogenomic allele discovery.Human mutation · 2022Article
- Low NUDT15 expression levels due to biallelic NUDT15 variants and 6-mercaptopurine intolerance.British journal of haematology · 2022Article
- Impact of T-cell immunity on chemotherapy response in childhood acute lymphoblastic leukemia.Blood · 2022Article
- Review
- NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells.Journal of cellular and molecular medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 10 institutions in 4 countries.
Rina NishiiDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Takaya MoriyamaDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0001-8864-4174
Laura J JankeDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
Wenjian YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Chase C SuiterDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-3716-8275
Ting-Nien LinDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Lie LiDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Kentaro KihiraDepartment of Pediatrics, Graduate School of Medicine, Mie University, Mie, Japan.
Hidemi ToyodaDepartment of Pediatrics, Graduate School of Medicine, Mie University, Mie, Japan.
Ute HofmannDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Matthias SchwabDr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany.
Masatoshi TakagiDepartment of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Tomohiro MorioDepartment of Pediatrics and Developmental Biology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Atsushi ManabeSt. Luke's International Hospital, Tokyo, Japan.
Shirley KhamKhoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore.
Nan JiangKhoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore.
Karen R RabinTexas Children's Cancer Center, Baylor College of Medicine, Houston, TX.
Motohiro KatoDepartment of Pediatric Hematology and Oncology Research, National Center for Child Health and Development, Tokyo, Japan.
Katsuyoshi KohDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.
Allen Eng-Juh YeohKhoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore.
Hiroki HoriDepartment of Pediatrics, Graduate School of Medicine, Mie University, Mie, Japan.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-0770-9659
St. Jude Children's Research Hospital · USMie University · JPTokyo Medical and Dental University · JPDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology · DENational University Hospital · SGBaylor College of Medicine · USNational Center For Child Health and Development · JPNational University of Singapore · SGSaitama Children's Medical Center · JPSt. Luke's International Hospital · JP
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LOH, MIGNON LEE-CHEUN, RELLING, MARY V · 2015 to 2019
$15.1MGenetics-guided Individualization of Thiopurine TherapyR01GM118578 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2017 to 2020
$2.2MNCI NIH HHS P30 CA021765NIGMS NIH HHS P50 GM115279NIGMS NIH HHS R01 GM118578
Abstract
Thiopurines (eg, 6-mercaptopurine [MP]) are highly efficacious antileukemic agents, but they are also associated with dose-limiting toxicities. Recent studies by us and others have identified inherited
Indexed as
AnimalsAntimetabolites, AntineoplasticChildCRISPR-Cas SystemsDrug Dosage CalculationsDrug Evaluation, PreclinicalGene DeletionGene EditingGenotypeHumansLeukemiaMercaptopurineMiceMice, KnockoutNudix HydrolasesPhosphoric Diester HydrolasesAntimetabolites, AntineoplasticMercaptopurineNudix HydrolasesNUDT15 protein, humanNudt15 protein, mousePhosphoric Diester HydrolasesPyrophosphatases
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.