ArticleJournal of epidemiology and community health2018
Systemic inflammation and suicide risk: cohort study of 419 527 Korean men and women.
Article in Journal of epidemiology and community health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- Pursuing the elusive biosignature for suicide: a decennial update.Molecular psychiatry · 2026Review
- Clustering of lifestyle risk factors in relation to suicidal thoughts and behaviors in young adolescents: a cross-national study of 45 low- and middle-income countries.BMC global and public health · 2024Article
- Article
- Spatiotemporal clustering of suicide attempt in Kermanshah, West-Iran.Frontiers in psychiatry · 2023Article
- Suicide attempt rate and the risk factors in young, first-episode and drug-naïve Chinese Han patients with major depressive disorder.BMC psychiatry · 2022Article
- Does the moderator matter? Identification of multiple moderators of the association between peripheral inflammatory markers and depression severity in a large racially diverse community cohort.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Association between dietary and suicidal behaviors in adolescents in Korea based on the Youth Risk Behavior Survey (2015-2020).Epidemiology and health · 2022Article
- New frontiers in suicide vulnerability: immune system and sex hormones.Brain, behavior, & immunity - health · 2021Article
- Investigating evidence for a causal association between inflammation and self-harm: A multivariable Mendelian Randomisation study.Brain, behavior, and immunity · 2020Article
- An inflammatory profile linked to increased suicide risk.Journal of affective disorders · 2019Article
Corrections and comments
- Erratum issuedCorrection:2018
Authors and funding
5 authors.
Funding
Abstract
backgroundData from only one study have been used to examine the relationship between systemic inflammation and later suicide risk, and a strong positive association was apparent. More research is needed, particularly looking at gender, not least because women are seemingly more vulnerable to inflammation-induced mood changes than men.
methodsThe Korean Cancer Prevention Study had a cohort of over 1 million individuals aged 30-95 years at baseline examination between 1992 and 1995, when white blood cell count, our marker of systemic inflammation, was assessed.
resultsA mean of 16.6 years of mortality surveillance gave rise to 1010 deaths from suicide in 106 643 men, and 1019 deaths from suicide in 312 884 women. There was little evidence of an association between our inflammation marker and suicide mortality in men after multiple adjustments. In women, however, those in the second inflammation quartile and higher experienced around 30% increase risk of death (HR 1.35; 95% CI: 1.11-1.64).
conclusionsHigher levels of systemic inflammation were moderately related to an elevated risk of suicide death in women but not in men.
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