Evidence map›Paper›PMID 29572283›Full record

ArticleNeurology2018

Cerebellar volume as an imaging marker of development in infants with tuberous sclerosis complex.

Siddharth Srivastava, Anna K Prohl, Benoit Scherrer, Kush Kapur, Darcy A Krueger, Simon K Warfield, Mustafa Sahin, TACERN Study Group

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01780441 (Longitudinal Study to Identify Early Biomarkers of Autism Spectrum Disorder), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01780441 completednot on this map

Longitudinal Study to Identify Early Biomarkers of Autism Spectrum Disorder (ASD) in Infants With Tuberous Sclerosis Complex (TSC)

TypeobservationalSponsorBoston Children's HospitalRan2013 to 2020Enrolled166ConditionsTuberous Sclerosis Complex
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Resting-State fMRI Networks in Children with Tuberous Sclerosis Complex.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Siddharth SrivastavaFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Anna K ProhlFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Benoit ScherrerFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Kush KapurFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Darcy A KruegerFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Simon K WarfieldFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH.
Mustafa SahinFrom the Departments of Neurology (S.S., K.K., M.S.) and Radiology (A.K.P., B.S., S.K.W.), Boston Children's Hospital, Harvard Medical School, Boston, MA; and Department of Pediatrics (D.A.K.), Division of Neurology, Cincinnati Children's Hospital Medical Center, OH. mustafa.sahin@childrens.harvard.edu.
TACERN Study Group
Boston Children's Hospital · USHarvard University · US

Funding

Toward better characterization and clinical trial readiness for targeting neuropsychiatric manifestations in PTEN pathogenic variantsU54NS092090 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI M. Pilar Trelles · 2014 to 2026
$20.1M
Early Biomarkers of Autism Spectrum Disorders in infants with Tuberous SclerosisU01NS082320 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI KRUEGER, DARCY, SAHIN, MUSTAFA · 2012 to 2018
$13.3M
TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
MRI Biomarkers of Patients with Tuberous Sclerosis Complex and AutismR01NS079788 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI WARFIELD, SIMON K · 2013 to 2017
$3.6M
NICHD NIH HHS U54 HD090255NIGMS NIH HHS T32 GM007748NINDS NIH HHS R01 NS079788NINDS NIH HHS U01 NS082320NINDS NIH HHS U54 NS092090
6 · The paper itself

Abstract

objectiveIn this cohort analysis, we studied 1-year-old infants with tuberous sclerosis complex (TSC), correlating volumes of cerebellar structures with neurodevelopmental measures.

methodsWe analyzed data from a prospective biomarker study in infants with TSC (ClinicalTrials.gov NCT01780441). We included participants aged 12 months with an identified mutation of

resultsThere were 70 participants (mean age 1.03 [0.11] years): n = 11 had a

conclusionsCerebellar volume loss-perhaps reflecting Purkinje cell degeneration-may predict neurodevelopmental severity in patients with

Indexed as

Magnetic Resonance ImagingCerebellumCognition DisordersCohort StudiesFemaleHumansImage Processing, Computer-AssistedInfantMaleMutationNeuropsychological TestsTuberous SclerosisTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 ProteinTSC1 protein, humanTSC2 protein, humanTuberous Sclerosis Complex 1 ProteinTuberous Sclerosis Complex 2 Protein

Identifiers

PMID29572283
PMCPMC5921037
OpenAlexW2794188004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.