Evidence map›Paper›PMID 29571898›Full record

ArticleBrain, behavior, and immunity2018

Differential immune responses and microbiota profiles in children with autism spectrum disorders and co-morbid gastrointestinal symptoms.

Destanie R Rose, Houa Yang, Gloria Serena, Craig Sturgeon, Bing Ma, Milo Careaga, Heather K Hughes, Kathy Angkustsiri, Melissa Rose, Irva Hertz-Picciotto and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 12 pooled it
15.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 12 syntheses or guidelines pooled it, 214 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Pooled it
  12. Pooled it
  13. Trial
  14. Trial
  15. Trial
  16. Trial
  17. Article
  18. Article
  19. Article
  20. Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Destanie R RoseDepartment of Medical Microbiology and Immunology, University of California Davis, USA; MIND Institute, University of California Davis, USA.
Houa YangDepartment of Medical Microbiology and Immunology, University of California Davis, USA; MIND Institute, University of California Davis, USA.
Gloria SerenaDivision of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, MassGeneral Hospital for Children, Boston, MA, USA; Graduate Program in Life Sciences University of Maryland School of Medicine, Baltimore, MD, USA.
Craig SturgeonDivision of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, MassGeneral Hospital for Children, Boston, MA, USA; Graduate Program in Life Sciences University of Maryland School of Medicine, Baltimore, MD, USA.
Bing MaInstitute of Genomic Science, University of Maryland School of Medicine, Baltimore, MD, USA.
Milo CareagaDepartment of Medical Microbiology and Immunology, University of California Davis, USA; MIND Institute, University of California Davis, USA.
Heather K HughesDepartment of Medical Microbiology and Immunology, University of California Davis, USA; MIND Institute, University of California Davis, USA.
Kathy AngkustsiriMIND Institute, University of California Davis, USA; Department of Pediatrics, University of California Davis, USA; Children's Center for Environmental Health, University of California Davis, CA, USA.
Melissa RoseChildren's Center for Environmental Health, University of California Davis, CA, USA; Public Health Sciences, University of California Davis, CA, USA.
Irva Hertz-PicciottoMIND Institute, University of California Davis, USA; Children's Center for Environmental Health, University of California Davis, CA, USA; Public Health Sciences, University of California Davis, CA, USA.
Judy Van de WaterMIND Institute, University of California Davis, USA; Children's Center for Environmental Health, University of California Davis, CA, USA; Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis, CA, USA.
Robin L HansenMIND Institute, University of California Davis, USA; Department of Pediatrics, University of California Davis, USA; Children's Center for Environmental Health, University of California Davis, CA, USA.
Jacques RavelInstitute of Genomic Science, University of Maryland School of Medicine, Baltimore, MD, USA.
Alessio FasanoDivision of Pediatric Gastroenterology and Nutrition, Center for Celiac Research, MassGeneral Hospital for Children, Boston, MA, USA.
Paul AshwoodDepartment of Medical Microbiology and Immunology, University of California Davis, USA; MIND Institute, University of California Davis, USA; Children's Center for Environmental Health, University of California Davis, CA, USA. Electronic address: pashwood@ucdavis.edu.
Center for Environmental Health · USUniversity of California, Davis · USMassachusetts General Hospital · USChildren's Center · USUniversity of Maryland, Baltimore · US

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
UC Davis Environmental Health Sciences Core CenterP30ES023513 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Nicholas J. KENYON · 2015 to 2026
$26.0M
THE CHARGE STUDY: CHILDHOOD AUTISM RISKS FROM GENETICS AND THE ENVIRONMENT - ADMINISTRATIVE SUPPLEMENTR01ES015359 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HERTZ-PICCIOTTO, IRVA · 2007 to 2019
$13.8M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAGERMAN, RANDI J. · 2013 to 2019
$8.5M
Zot, Zonulin, and Pathophysiology of Intestinal Tight JunctionsR01DK048373 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FASANO, ALESSIO · 1996 to 2015
$4.4M
Immune regulation and gastrointestinal co-morbidity in autism spectrum disordersR01HD090214 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2018 to 2022
$1.9M
The effects of environmental air pollutants on maternal allergic asthma and its neurobiological consequencesR21ES025560 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2017 to 2018
$432k
Immune regulation and neurodevelopmental disordersR21HD086669 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL, SILVERMAN, JILL LYNN · 2016 to 2017
$432k
Maternal asthma and brain developmentR21MH116383 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ASHWOOD, PAUL · 2018 to 2019
$432k
Autism Speaks AS7567Autism Speaks ASCN5014NCATS NIH HHS UL1 TR001860NCRR NIH HHS UL1 RR024146NICHD NIH HHS R21 HD086669NICHD NIH HHS U54 HD079125NIDDK NIH HHS R01 DK048373NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES023513NIEHS NIH HHS R01 ES015359NIEHS NIH HHS R21 ES025560NIMH NIH HHS R21 MH116383
6 · The paper itself

Abstract

objectivesMany studies have reported the increased presence of gastrointestinal (GI) symptoms in children with autism spectrum disorders (ASD). Altered microbiome profiles, pro-inflammatory responses and impaired intestinal permeability have been observed in children with ASD and co-morbid GI symptoms, yet few studies have compared these findings to ASD children without GI issues or similarly aged typical developing children. The aim of this study was to determine whether there are biological signatures in terms of immune dysfunction and microbiota composition in children with ASD with GI symptoms.

methodsChildren were enrolled in one of four groups: ASD and GI symptoms of irregular bowel habits (ASD

resultsFollowing Toll-Like receptor (TLR)-4 stimulation, the ASD

conclusionsOverall our findings suggest that children with ASD who experience GI symptoms have an imbalance in their immune response, possibly influenced by or influencing metagenomic changes, and may have a propensity to impaired gut barrier function which may contribute to their symptoms and clinical outcome.

Indexed as

Autism Spectrum DisorderChildChild DevelopmentChild, PreschoolComorbidityCytokinesFemaleGastrointestinal DiseasesGastrointestinal MicrobiomeHumansLeukocytes, MononuclearMaleMicrobiotaMonocytesCytokinesASDAutismCytokinesGastrointestinalImmuneMicrobiotaMucosal ImmunityZonulin

Identifiers

PMID29571898
PMCPMC5953830
OpenAlexW2793162366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.