ArticleBioorganic & medicinal chemistry letters2018
Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.
Article in Bioorganic & medicinal chemistry letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Cystinuria in children: diagnosis and treatment.World journal of urology · 2025Review
- Discovery of l-Lysine Dioxalate (LH1513) as a Novel Inhibitor of Calcium Oxalate Crystallization for Hyperoxaluria.ACS medicinal chemistry letters · 2024Article
- Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2024Article
- 8-l-Cystinyl Bis(1,8-diazaspiro[4.5]decane) as an Orally Bioavailable l-Cystine Crystallization Inhibitor for Cystinuria.ACS medicinal chemistry letters · 2024Article
- The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9Redox biology · 2023Article
- Development of convenient crystallization inhibition assays for structure-activity relationship studies in the discovery of crystallization inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2023Article
- A Summary of Current Guidelines and Future Directions for Medical Management and Monitoring of Patients with Cystinuria.Healthcare (Basel, Switzerland) · 2023Article
- Cystinuria: an update on pathophysiology, genetics, and clinical management.Pediatric nephrology (Berlin, Germany) · 2022Review
- Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.Accounts of chemical research · 2022Article
- Evaluation and Medical Management of Patients with Cystine Nephrolithiasis: A Consensus Statement.Journal of endourology · 2020Article
- Update on cystine stones: current and future concepts in treatment.Intractable & rare diseases research · 2020Review
- Cystinuria: genetic aspects, mouse models, and a new approach to therapy.Urolithiasis · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl ester (CME), a series of l-cystine diamides with or without N
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.