Evidence map›Paper›PMID 29571294›Full record

ArticleAnnals of clinical microbiology and antimicrobials2018

Detection of Neisseria meningitidis in a paediatric patient with septic arthritis using multiplexed diagnostic PCR targeting meningitis/encephalitis (ME).

Donnchadh O'Sullivan, Barry Linnane, Amanda Mostyn, Nteimam Jonathan, Marie Lenihan, Nuala H O'Connell, Colum P Dunne

Open access · goldAbstract readCase Reports
In one paragraph

Article in Annals of clinical microbiology and antimicrobials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Donnchadh O'SullivanDepartment of Clinical Microbiology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Barry LinnaneDepartment of Paediatrics, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Amanda MostynDepartment of Clinical Microbiology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Nteimam JonathanDepartment of Clinical Microbiology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Marie LenihanDepartment of Clinical Microbiology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Nuala H O'ConnellDepartment of Clinical Microbiology, University Hospital Limerick, Dooradoyle, Limerick, Ireland.
Colum P DunneCentre for Interventions in Infection, Inflammation & Immunity (4i) and Graduate Entry Medical School, University of Limerick, Limerick, Ireland. colum.dunne@ul.ie.
University Hospital Limerick · IEUniversity of Limerick · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeisseria meningitidis is associated with meningitis and septicemia. Septic meningococcal arthritis is relatively uncommon and its diagnosis associated with clinical and microbiological challenges. Early recognition and treatment is required to prevent joint destruction. PURPOSE: We describe a case of an eleven-year-old boy with septic arthritis and the first reported use of a multiplexed diagnostic PCR test, capable of simultaneous rapid detection of 14 pathogens directly from CSF samples, to determine presence of N. meningitides in a synovial fluid sample.

resultsIn this case, blood cultures and an aspiration of the joint fluid were negative for microbial growth, but leucocytes were present. Analysis of samples using the multiplexed FilmArray

conclusionsThis case demonstrates difficulties associated with clinical and microbiological diagnosis of primary septic meningococcal arthritis. We describe the first successful use of the FilmArray

Indexed as

Arthritis, InfectiousCerebrospinal FluidChildDNA, BacterialEncephalitisHumansMaleMeningitis, MeningococcalMolecular Diagnostic TechniquesMultiplex Polymerase Chain ReactionNeisseria meningitidisRNA, Ribosomal, 16SSepsisDNA, BacterialRNA, Ribosomal, 16SArthritisMeningococcalMultiplexedNeisseria meningitidisPCRSepticemia

Identifiers

PMID29571294
PMCPMC5865334
OpenAlexW2794996943

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.