Evidence map›Paper›PMID 29571174›Full record

ArticlePlanta medica2018

Integration of Biochemometrics and Molecular Networking to Identify Antimicrobials in Angelica keiskei.

Lindsay K Caesar, Joshua J Kellogg, Olav M Kvalheim, Richard A Cech, Nadja B Cech

Abstract read
In one paragraph

Article in Planta medica, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
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  9. Pharmaceuticals (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lindsay K CaesarDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina.
Joshua J KelloggDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina.
Olav M KvalheimDepartment of Chemistry, University of Bergen, Bergen, Norway.
Richard A CechStrictly Medicinal Seeds, Williams, Oregon.
Nadja B CechDepartment of Chemistry and Biochemistry, The University of North Carolina at Greensboro, Greensboro, North Carolina.

Funding

Strategies to Investigate Synergy in Botanical MedicinesR01AT006860 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI CECH, NADJA B · 2013 to 2017
$1.8M
Predoctoral Training: Innovative Technologies for Natural Products and Integrative Medicine ResearchT32AT008938 · NCCIH · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Nadja B Cech, Jonathan Rodi Chekan · 2016 to 2026
$1.6M
NCCIH NIH HHS R01 AT006860NCCIH NIH HHS T32 AT008938
6 · The paper itself

Abstract

Botanical medicines have been utilized for centuries, but it remains challenging to identify bioactive constituents from complex botanical extracts. Bioassay-guided fractionation is often biased toward abundant or easily isolatable compounds. To comprehensively evaluate active botanical mixtures, methods that allow for the prioritization of active compounds are needed. To this end, a method integrating bioassay-guided fractionation, biochemometric selectivity ratio analysis, and molecular networking was devised and applied to

Indexed as

AngelicaAnti-Infective AgentsBiological AssayChalconeChromatography, LiquidMass SpectrometryMethicillin-Resistant Staphylococcus aureusMicrobial Sensitivity TestsMolecular StructurePlant ExtractsPlant RootsStaphylococcus aureus4-hydroxyderricinAnti-Infective AgentsChalconePlant Extractsxanthoangelol

Identifiers

PMID29571174
PMCPMC6277903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.