ArticleCell2018
A Neural Circuit for the Suppression of Pain by a Competing Need State.
Article in Cell, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
124 citing papers in PubMed, 225 citations in OpenAlex.
- A hypothalamic circuit links hunger to mesolimbic dopamine to drive feeding.bioRxiv : the preprint server for biology · 2026Article
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- Hypothalamic prolactin receptorNature communications · 2026Article
- ParabrachialProceedings of the National Academy of Sciences of the United States of America · 2026Article
- An attention-demanding hunting paradigm engages the superior colliculus-zona incerta circuit mediating analgesia in male mice.Nature communications · 2026Article
- The gatekeeper of ongoing pain: an endogenous analgesic circuit that prioritizes survival.Nature reviews. Neuroscience · 2026Article
- Lateral hypothalamus directs stress-induced modulation of acute and psoriatic itch.Cell reports · 2026Article
- A corticothalamic circuit modulates pain sensitivity and mediates innate fear-induced analgesia in male mice.Nature communications · 2026Article
- IL-1β engages distinct peripheral sensory circuits to suppress feeding across time.bioRxiv : the preprint server for biology · 2026Article
- Sex-specific differences in mediobasal hypothalamus in response to nutritional states.Nature communications · 2026Article
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
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- Article
- The pharmacotherapeutic potential of neuropeptide Y for chronic pain.Journal of internal medicine · 2025Review
- Article
- Synergistic deficits in parvalbumin interneurons and dopamine signaling drive ACC dysfunction in chronic pain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A top-down insular cortex circuit crucial for non-nociceptive fear learning.Science advances · 2025Article
- Article
- Endogenous opioid receptors and the feast or famine of maladaptive feeding.Nature communications · 2025Review
- An intra-brainstem circuitry for pain-induced inhibition of itch.Neuroscience · 2025Article
64 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Hunger and pain are two competing signals that individuals must resolve to ensure survival. However, the neural processes that prioritize conflicting survival needs are poorly understood. We discovered that hunger attenuates behavioral responses and affective properties of inflammatory pain without altering acute nociceptive responses. This effect is centrally controlled, as activity in hunger-sensitive agouti-related protein (AgRP)-expressing neurons abrogates inflammatory pain. Systematic analysis of AgRP projection subpopulations revealed that the neural processing of hunger and inflammatory pain converge in the hindbrain parabrachial nucleus (PBN). Strikingly, activity in AgRP → PBN neurons blocked the behavioral response to inflammatory pain as effectively as hunger or analgesics. The anti-nociceptive effect of hunger is mediated by neuropeptide Y (NPY) signaling in the PBN. By investigating the intersection between hunger and pain, we have identified a neural circuit that mediates competing survival needs and uncovered NPY Y1 receptor signaling in the PBN as a target for pain suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.