Evidence map›Paper›PMID 29570931›Full record

ArticlePigment cell & melanoma research2018

Uveal melanoma driver mutations in GNAQ/11 yield numerous changes in melanocyte biology.

Dahlia E Perez, Andrea M Henle, Adam Amsterdam, Hannah R Hagen, Jacqueline A Lees

Open access · bronzeAbstract read
In one paragraph

Article in Pigment cell & melanoma research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Article
  3. A dual ribosomal system in the zebrafish soma and germline.bioRxiv : the preprint server for biology · 2024
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. MITF deficiency accelerates GNAQ-driven uveal melanoma.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  10. Animal Models of Uveal Melanoma.Annals of eye science · 2022
    Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. The Latest on Uveal Melanoma Research and Clinical Trials: Updates from the Cure Ocular Melanoma (CURE OM) Science Meeting (2019).Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  16. Review
  17. Update onCancers · 2020
    Review
  18. Review
  19. Uveal melanoma: progress in molecular biology and therapeutics.Therapeutic advances in medical oncology · 2020
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dahlia E PerezDepartment of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andrea M HenleDepartment of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Adam AmsterdamDepartment of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Hannah R HagenDepartment of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jacqueline A LeesDepartment of Biology and The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Massachusetts Institute of Technology · USCarthage College · US

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
PRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8M
Melanoma Research AllianceNCI NIH HHS P30 CA014051NIGMS NIH HHS T32 GM007287The Kathy and Curt Marble Cancer Research Fund
6 · The paper itself

Abstract

Uveal melanoma (UM) is the most common primary intraocular cancer and has a high incidence of metastasis, which lacks any effective treatment. Here, we present zebrafish models of UM, which are driven by melanocyte-specific expression of activating GNAQ or GNA11 alleles, GNAQ/11

Indexed as

MutationAnimalsAnimals, Genetically ModifiedCells, CulturedGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11HumansHyperpigmentationMelanocytesMelanomaPrecancerous ConditionsUveal MelanomaUveal NeoplasmsZebrafishGNA11 protein, humanGNAQ protein, humanGTP-Binding Protein alpha SubunitsGTP-Binding Protein alpha Subunits, Gq-G11GNA11GNAQmelanocytemelanophoreuveal melanomazebrafish

Identifiers

PMID29570931
PMCPMC6151293
OpenAlexW2793103703

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.